FORMULATION, DEVELOPMENT, EVALUATION OF CLOBAZAM AND SOLUBILITY, BIOAVAILABILITY ENHANCEMENT BY SOLID DISPERSION TECHNIQUES

Abstract

In this study, aim was to formulate Clobazam solid dispersions to modify the drug's solubility and enhance therapeutic effect. Clobazam suffers from poor aqueous solubility, which limits its bioavailability. Solid dispersions were prepared using as carriers in different drug-to-carrier ratios through solvent evaporation and physical mixing techniques. These dispersions were assessed for bulk density, particle size, tapped density, angle of repose, also drug release profile. The aim of this study was to enhance the dissolution rate of Clobazam using solid dispersion systems. Solid dispersion is a highly effective pharmaceutical strategy used to enhance the solubility and bioavailability of poorly water-soluble drugs. It works by dispersing a crystalline drug in an amorphous state within a hydrophilic polymer matrix, drastically increasing surface area and wettability. Solid dispersions are an effective method of increasing the solubility and bioavailability of poorly soluble drugs. In the present study  to enhance solubility of Clobazam a poorly soluble drug by solid dispersion technique by employing solvent evaporation technique using PVP K 30 And PEG 8000 as carriers.. The prepared solid dispersions showed excellent improvement of drug solubility due to mean drug particle size reduction which lead to increase drug dissolution and bioavailability.