DETERMINATION OF TOTAL CORTISOL LEVEL IN BLOOD SERUM

Abstract

Relevance of the problem. In recent years, the problem of connective tissue dysplasia, the most common and frequently diagnosed manifestation of which is mitral valve prolapse, has attracted the close attention of researchers. MVP is diagnosed, according to various sources, in 1.8% to 38% of the population. Of particular importance is the fact that most individuals with newly diagnosed MVP are young, and assessing their ability to work, childbearing potential, and military service is of great practical importance. The prognosis for MVP, the need for, and methods of treatment remain poorly understood. The etiology and pathogenesis of MVP require clarification. The literature suggests the presence of a genetically determined defect in collagen synthesis, a decrease in interstitial magnesium ( Mg ), a deficiency of which leads fibroblasts to produce defective collagen in the mitral valve leaflets. Skin is one of the most accessible structures for studying the characteristics of dysplasia. There are isolated reports in the literature on skin structure studies in patients with mitral valve prolapse. The need to study this issue appears important and may, to some extent, clarify some aspects of mitral valve prolapse pathogenesis and serve as a method for monitoring treatment effectiveness. It is believed that various clinical symptoms in patients with MVP are also dependent on Mg deficiency . Studying certain aspects of Mg metabolism and its impact on the dynamics of MVP is highly relevant. The increased incidence of infectious diseases may also be related to this, as Mg deficiency leads to immune system dysregulation . The state of the interferon system in individuals with MVP has not been studied. The role of psychovegetative and hormonal disturbances in the structure of MVP is still debated. Determining the level of cortisol, a stress hormone and one of the main immune-regulatory hormones, may reveal clinical, immune, and hormonal correlations that explain disturbances in the immune system and neuropsychiatric status. We found no studies of K levels in these individuals in the available literature. Most publications indicate a significant prevalence of anxiety disorders in patients with MVP, reaching 31.0-44.6%. A hypothesis has been advanced regarding the possibility of "functional" MVP developing within panic disorder. Several authors argue that panic attacks can not only be "initiated" by MVP but can also lead to the development of its symptoms. The lack of consensus on this issue underscores the relevance of studying psychopathological changes in individuals with MVP.