THE ROLE OF 6-BROMOQUINAZOLINE-2,4-DIONE IN MODERN MEDICINAL CHEMISTRY: STRUCTURAL FEATURES, BIOLOGICAL ACTIVITY, AND THERAPEUTIC PROSPECTS

Abstract

Quinazoline derivatives represent a prominent class of nitrogen-containing heterocyclic compounds with extensive applications in medicinal chemistry. Among them, quinazoline-2,4-dione scaffolds have attracted considerable attention due to their diverse biological activities. The incorporation of halogen atoms, particularly bromine at the C-6 position, significantly alters the physicochemical and pharmacokinetic properties of these molecules. This paper provides a comprehensive analysis of 6-bromoquinazoline-2,4-dione, focusing on its structural characteristics, synthetic methodologies, and pharmacological potential. Special emphasis is placed on its anticancer, antiviral, and antimicrobial activities, along with a discussion of molecular mechanisms and future therapeutic perspectives.