HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF PROPRANOLOL AND FLUNARIZINE IN COMBINED DOSAGE FORM

Abstract

This work presents the development and validation of a high-performance liquid chromatography (HPLC) method for the simultaneous estimation of Propranolol (PNL) and Flunarizine (FNZ) in pharmaceutical formulations. The method was subjected to a comprehensive validation process, including linearity, recovery studies, precision assessment, sensitivity determination, and assay of tablet formulations. The results demonstrated the method's accuracy, precision, and sensitivity, making it a robust tool for routine analysis in pharmaceutical laboratories. The successful application of the method to assess the assay of tablet formulations further underlines its practical utility in pharmaceutical quality control.

Keywords: HPLC, Propranolol, Flunarizine, Method Development, Method Validation, Pharmaceutical Formulations, Quality Control.