FORMULATION & EVALUATION OF MUCOADHESIVE BUCCAL FILM OF MEFENAMIC ACID
Abstract
This novel formulation (buccal film) was designed particularly for antiinflammatory and analgesic therapy in the oral cavity. The advantages reside on the reduction of drug dose because of its localization in the inflammatory process site.One particular problem to drug delivery system, aim to the treatment of the oral cavity disease, is the short residence time at the site of application. This problem may be resolved by using bioadhesive polymer i.e. - polymer that exhibit characteristic adhesive interaction with biological membrane. Recently various bioadhesive mucosal dosage forms including adhesive tablets, gels and recently films have been developed. However, buccal films are preferable over adhesive tablet in terms of flexibility and convenience. In addition they can increase short residence time of oral gels on the mucosa which are easily washed and removed by saliva. Moreover buccal films are also suitable for protecting wound surfaces, thus reducing pain and increasing treatment effectiveness. In vitro drug release of this film showed that mefenamic acid was rapidly released during the first 1hrs (35%), and the release was completed after 6 hr and 30 min. % drug release after 6 hr. was found out to be 62% for film code MF1 and for film code MF7, MF8 and MF9 found to be 63%.
Keywords: Buccal film, Bioadhesive polymer, Mefenamic acid.
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