“SOLID AS SOLVENT”- NOVEL SPECTROPHOTOMETRIC ANALYSIS OF PIROXICAM TABLETS USING PHENOL AS SOLVENT
Abstract
The pollution and toxicity caused by most of the organic solvents is a big challenge. The researchers are doing much work to give eco-friendly solutions for this challenge. Maheshwari has given a nice concept, known as mixed-solvency concept. By application of this concept, innumerable solvent systems can be developed. Maheshwari is of the opinion that each substance possesses solubilizing power. He has given several eco-friendly methods in the area of drug estimations and formulations precluding the use of toxic organic solvents. The present research work also provides an eco-friendly method to estimate spectrophotometrically, a poorly water-soluble drug, piroxicam in tablet formulations without the help of organic solvent. The present investigation is an attempt to show that solids can also be wisely used to act as solvent precluding the use of organic solvents. The main objective of the present study is to demonstrate the solvent action of solid. In the present investigation melted phenol was employed as solubilizing substance to extract out the drug to estimate piroxicam tablets spectrophotometrically at 358 nm. Phenol does not interfere in spectrophotomeric analysis above 300 nm. Proposed method is novel, economic, eco-friendly, rapid, free from toxicity of organic solvent, accurate and reproducible. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the proposed method. The presence of tablet excipients and phenol did not interfere in the spectrophotometric estimation at 358 nm.
Keywords - Mixed-solvency concept, piroxicam, phenol, spectrophotometric analysis.
References
Maheshwari RK. “Mixed-solvency approach”- Boon for solubilization of poorly water-soluble drugs. Asian J Pharm 2010;4(1):60-3.
Maheshwari RK. Solubilization of ibuprofen by mixed solvency approach. Indian Pharm 2009;8(87):81-4.
Maheshwari RK. “Mixed- solvency” – A novel concept for solubilization of poorly water-soluble drugs. Delving J. Tech Eng Sci 2009;1(1):39-43.
Maheshwari RK. “Solid as solvent”- Novel spectophotometric analysis of satranidazole tablets using phenol as solvent”. Indian Pharm 2014;12:37-40.
Maheshwari RK. “Solid as solvent”- Novel spectophotometric analysis of norfloxacin
tablets using phenol as solvent”. Int J Curr Pharm Res 2014;6:76-8.
Maheshwari RK. Potentiation of solvent character by mixed solvency concept: A novel concept of solubilization. J Pharm Res 2010;3(2):411-3.
Maheshwari RK, Shilpkar R. Formulation development and evaluation of injection of poorly soluble drug using mixed solvency concept. Int J Pharm Biosci 2012;3(1):179-
Maheshwari RK, Upadhyay N, Jain J, Patani M, Mathuria KC. New spectrophotometric estimation of naproxen tablet formulation employing mixed solvency concept (at 331 nm). Int J Pharm Technol 2011;3(4):3618-23.
Maheshwari RK, Rajagopalan R. Formulation and evaluation of tinidazole syrup made by mixed-solvency concept. Der Pharm Lett 2011;3(6):266-71.
Maheshwari RK, Karawande VU, Application of novel concept of mixed solvency in the design and development of floating microspheres of furosemide. Int J Pharm Pharm Sci 2013,15:167-95.
Maheshwari RK, Upadhyay N, Jain J, Patani M, Pandey R. New spectrophotometric analysis of gatifloxacin tablets utilizing mixed solvency concept (at 288 nm). Der Pharm Lett 2012;4(1):1-4.
Prashant B, Rawat S, Mahajan YY, Galgatte UC, Maheshwari RK. Formulation development and evaluation of aqueous injection of poorly soluble drug made by novel application of mixed solvency concept. Int J Drug Delivery 2013;2:152-66.
Maheshwari RK, Rajagopalan R. Formulation and evaluation of paracetamol syrup made by mixed-solvency concept. Der Pharm Lett 2012;4(1):170-4.
Chandna C, Maheshwari RK. Mixed solvency concept in reducing surfactant concentration of self emulsifying drug delivery systems of candesartan cilexetil using D-optimal mixture design. Asian J Pharm 2013;7(2):83-91.
Maheshwari RK, Upadhyay N, Jain J, Patani M, Mathuria KC. New spectrophotometric estimation of naproxen tablet formulation employing mixed solvency concept (at 331 nm). Int J Pharm Technol 2011;3(4):3618-23.
Agrawal A, Maheshwari RK. Formulation development and evaluation of in situ nasal gel of poorly water soluble drug using mixed solvency concept. Asian J Pharm 2011;5(3);131-40.
Bhawsar N, Maheshwari RK, Ansari A, Saktawat Y. New spectrophotometric estimation of gatifloxacin in the tablets using mixed solvency approach. Int J Pharm Sci 2011;2(2):270-4.
Soni LK, Solanki SS, Maheshwari RK. Solubilization of poorly water soluble drug using mixed solvency approach for aqueous injection. Br J Pharm Res 2014;4(5):549- 68.
Maheshwari RK, Gupta S, Gharia A, Garg SK, Shilpkar R. Simple eco-friendly spectrophotometric estimation of tinidazole tablets by application of mixed-ssolvency technique. Bull Pharm Res 2011;1(1):22-5.
Maheshwari RK. “Solid as solvent”-Novel spectrophotometric analysis of tinidazole tablets using melted phenol as solvent. Asian J Pharm Res 2015;5(1):21-24.
Maheshwari RK, Putliwala M, Padiyar A. Novel approach for spectrophotometric estimation of naproxen in tablet dosage form using solids (eutectic liquid of phenol and niacinamide) as solubilising agents. Asian J Pharm Res 2015;5(1):25-28.
Maheshwari RK. “Solid as solvent”-Novel spectrophotometric analysis of frusemide tablets using phenol as solvent. Bulletin of Pharmaceutical Research 2014;4(2):104-107.
Maheshwari RK. “Solid as solvent”-Novel spectrophotometric analysis of tinidazole tablets using melted phenol as solvent. Asian Journal of Pharmaceutical Research 2015;5(1):21-24.
Maheshwari, R. K., Padiyar,A, Putliwala, M., Utilization of mixed solvency technique in spectrophotometric analysis of cefixime trihydrate tablets, International Journal of Pharmaceutical Research and Analysis 2015;5(1):01-03.
Maheshwari RK, Fouzdar A, “Solid as solvent” - Novel approach for spectrophotometric estimation of solid dosage form of nalidixic acid using solids (eutectic liquid of phenol and niacinamide) as solubilizing agents (mixed solvency concept), European Journal of Biomedical and Pharmaceutical Sciences 2014; 1(3):424-430.
Maheshwari RK, Chaklan N, Singh S, Novel pharmaceutical application of mixed solvency concept for development of solid dispersions of piroxicam, European Journal of Biomedical and Pharmaceutical Sciences 2015;1(3):578-591.
Jain DK, Patel V, Banjare L, Jain N, Maheshwari RK, “Solid as solvent”- Novel spectrophotometric analysis of ornidazole tablets using melted phenol as solvent, Asian Journal of Biomedical and Pharmaceutical Sciences, 2014; 4(40):26-29.
Maheshwari RK, “Solid as solvent”- Novel spectrophotometric estimation of piroxicam tablets using solids (eutectic liquid of phenol and niacinamide) as solubilising agents (mixed solvency concept), The Pharma Review, 2015;Jan-Feb issue, 113-117.
