FORMULATION AND EVALUATION OF PHYTOSOME LOADED DRUG DELIVERY FOR THE TREATMENT OF RESPIRATORY INFECTION

Authors

  • Rajat Kumar Jaiswal
  • Mrs.Shikha Singh
  • Dr.Abhishek Banke
  • Dr.R.B Goswami

Abstract

Aim In this formulation of the Phytosome loaded delivery with 6-ginger for the treatment of respiratory infection and evaluate the formulation of phytosome formulation of drug and also complex formulation of drugs i.e. 6-ginger. For the study of formulation evaluation parameters are shape of phytosome, FT-IR, DSR, determination of % yield, partical size and entrapment efficiency of drug and in-vitro study also.To overcome these issues and make home grown treatment more viably for the treatment of RTI, novel drug delivery (nanoparticle) based phytosome loaded complex approach was adopted.The prepared nanoparticle based complex of phytosome loaded of both phyto constituent drugs have the combined effect of chitosan and phytosome

KEYWORDS:

Phytosome, Respiratory Infection, Nanoparticle, Novel drug delivery

References

Adhikari A, Sen K, Biswas S, Sengupta M. Role of imunomet in upper respiratory tract diorder: A randomized double blind placebo controlled clinical trial. Int. Res. J. Ayur. Pha. 2012; 3(4):505-507.

Eccles MP, Grimshaw JM, Johnston M. Applying psychological theories to evidence based clinical practice: identifying factors predictive of managing upper respiratory tract infections without antibiotics. Impl. Sci. 2: 26.2007; doi:10.1186/17485908226.

Ajazuddin, S. Saraf. Applications of novel drug delivery system for herbal formulations. Fitoterapia. 2010; 81: 680–689.

Khan J, Alexander A, Ajazuddin, Saraf S, Saraf S. Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. J. Contr. Rel. 2013; 168:50–60.

Singh RP, Narke R. Preparation and evaluation of phytosome of lawsone. Int. J. Pharm. Sci. Res. 2015; 6(12): 5217-5226.

Das MK, Kalita B. Design and evaluation of phyto-phospholipid complexes (phytosomes) of rutin for transdermal application. J. Appl. Pharm. Sci. 2014; 4 (10):051-057.

Keerthi B, Pingali PS, Srinivas P. Formulation and evaluation of capsules of ashwagandhaphytosomes. Int. J. Pharm. Sci. Rev. Res. 2014; 29(2): 138-142. References 165

Mannur VS, Majik KK, Mastiholimath VS, Furtado DA. Formulation and comparative studies of lovastatin loaded polymeric nanoparticles prepared by ionic gelation and solvent evaporation technique. Int. J. Pharm. Sci. Res. 2015; 6(11): 4796-4803.

Perkin Elmer FTIR Spectrum BX, USA, Instruction manual.

Fiese EF, Hagen TA. Pre-formulation. In: Lachman L, Lieberman H A, Kanig J L, (Eds.), The Theory and Practice of Ind. Pharm. Varghese Publishing House, Bombay 1987: 171-194.

Das MK, Kalita B. Design and evaluation of phyto-phospholipid complexes (phytosomes) of rutin for transdermal application. J. Appl. Pharm. Sci. 2014; 4 (10):051-057.

Bhattacharyya SS, Paul S, De A, Das D, Samadder A, Boujedaini N, KhudaBukhsh AR. Poly (lactide-co-glycolide) acid nano encapsulation of a synthetic coumarin: Cytotoxicity and bio-distribution in mice, in cancer cell line and interaction with calf thymus DNA as target. Toxicol. Appl. Pharmacol. 2011; 253:270–281.

Wang SB, Chen AZ, Weng LJ, Chen MY, Xie XL. Effect of drug-loading methods on drug load, encapsulation efficiency and release properties of alginate/poly-l-arginine/chitosan ternary complex microcapsules. Macromol. Biosci. 2004; 4:27–30.

Hou Z, Li Y, Huang Y, Zhou C, Lin J, Wang Y, Cui F, Zhou S, Jia M, Ye S, Zhang Q. Phytosomes loaded with mitomycin C−Soybean phosphatidylcholine complex developed for drug delivery. Mol. Pharmaceutics. 2013; 10: 90−101.

Pan Y, Wang K, Huang S, Wang H, Mu X, He C, Ji X, Zhang J, Huang F. Antioxidant activity of microwave-assisted extract of longan (Dimocarpuslongan Lour.) peel. Food Chem. 2008; 106: 1264 – 1270. doi: 10.1016/j.foodchem.2007.07.033.

Downloads

Published

2023-03-30

Issue

Section

Original Research Article