EVALUATION OF DIURETIC AND ANTIULCER ACTIVITY OF METHANOLIC EXTRACT OF LASIA SPINOSE (RHIZOME) IN RATS
Abstract
In the present study, the plant drug (100g) was subjected to extraction by (maceration) using Hydroalcohol as solvent for about 24 hrs. The yields were found to be (13.5% w/w of crude drug) of Hydroalcoholic extract Lasia spinosa rhizomes. The results of phytochemical revels that the all polar and Methanolic and aqueous soluble compound was found to be present in Lasia spinosa rhizomes extract.Oral administration of ethanol produced severe ulceration. The Hydroalcoholic extract of Lasia spinosa significantly reduced the incidence and severity of ulceration in ethanol-induced ulcer model. The animal treated with Hydroalcoholic extract of Lasia spinosa at the dose of 200 and 300 mg/kg per oral, produced significant decrease in ulcer index compared with disease . The extract at the dose of 200 and 300 mg/kg body weight afforded 36.62 and 54.41 % ulcer protection respectively, whereas Omeprazole (20 mg/kg) exhibited 70.41 % ulcer protection.
Key words: Lasia spinosa, TPC , TFC, Antiulcer and DiureticReferences
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