CISPLATIN INDUCES NEPHROTOXICITY IN RATS: MODULATORY ROLE OF HERBAL EXTRACTS AGAINST INFLAMMATION
Abstract
In the present study, we attempted to investigate the effect of hydroalcoholic and Curcuma caesia Roxb rhizomes on CP- induced nephrotoxicity in rats. Our results clearly showed that the hydroalcoholic extract of Curcuma caesia Roxb (rhizomes) inhibited the CP-induced increases of kidney damage biomarkers (BUN and creatinine). Pathological findings also confirmed the protective effect of the hydroalcoholic extract of Curcuma caesia Roxb. Hydroalcoholic extract of Curcuma caesia Roxb showed significant protective effect at doses of 250 and 350 mg/kg and unexpectedly the dose of 450 mg/kg was ineffective.
It seems that the dose of hydroalcoholic extract of Curcuma caesia Roxb is detrimental and higher doses lose activity. At present we do not have explanation for it and further studies are required to find out the reason. The hydroalcoholic extract of Curcuma caesia Roxb are good source of flavonoid compounds such as quercetin. The findings of many researches confirmed that these compounds are responsible for useful effects in oxidative stress.
On the other hand, several studies reported that the mechanism of CP nephrotoxicity can be associated with oxidative stress. As a result, the protective effect of hydroalcoholic extract of Curcuma caesia Roxb on CP-induced nephrotoxicity might be partly due to antioxidant potential of these compounds. Some investigators have reported that CP-induced nephrotoxicity has an inflammatory component and pro-inflammatory cytokines are involved in its pathogenesis.
Key words: Curcuma caesia Roxb, Cisplatin, Nephrotoxicity,
References
Thadhani R, Pascual M, Bonventre JV. Acute renal failure. N Engl J Med 1996;334:1448–60.
Arany I, Safirstein RL. Cisplatin nephrotoxicity. SeminNephrol2003;23:460–4.
Verma D, Srivastava S, Singh V, Rawat AK. Pharmacognostic evaluation of Curcuma caesia Roxb. rhizome. Natural Product Sciences. 2010;16(2):107-10.
Behar N, Tiwari KL, Jadhav SK. A review on non-conventional turmeric: Curcuma caesia Roxb. Current Trends in Biotechnology and Pharmacy. 2014;8(1):91-101.
Azwanida NN. A review on the extraction methods use in medicinal plants, principle, strength and limitation. Med Aromat Plants. 2015 Jul 6;4(196):2167-0412.
Shaikh JR, Patil M. Qualitative tests for preliminary phytochemical screening: An overview. International Journal of Chemical Studies. 2020 Mar;8(2):603-8.
Ainsworth EA, Gillespie KM. Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin–Ciocalteu reagent. Nature protocols. 2007 Apr;2(4):875-7.
Marjanovic A, Djedjibegovic J, Lugusic A, Sober M, Saso L. Multivariate analysis of polyphenolic content and in vitro antioxidant capacity of wild and cultivated berries from Bosnia and Herzegovina. Scientific reports. 2021 Sep 28;11(1):19259.
dos Santos NA, Carvalho Rodrigues MA, Martins NM, Dos Santos AC. Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update. Archives of toxicology. 2012 Aug;86:1233-50.
Eraslan G, Kanbur M, Silici S. Evaluation of propolis effects on some biochemical parameters in rats treated with sodium fluoride. Pesticide Biochemistry and Physiology. 2007 Jul 1;88(3):273-83.
Padmini MP, Kumar JV. A histopathological study on gentamycin induced nephrotoxicity in experimental albino rats. IOSR J Dent Med Sci. 2012 Jul;1(1):14-7.
