EVALUATION OF ANTIPYRETIC POTENTIAL OF HYDROALCOHOLIC EXTRACT OF AERVALANATA LEAVES

Abstract

Pyrexia occurs due to infection, malignancy and other diseases. Majority of the antipyretic drugs are synthetic in nature which exerts side effects such as gastric ulcer, hepatic necrosis and renal damage. The antipyretic potential of the hydro-alcoholic extracts Aervalanatawere investigated on the brewer's yeastpyrexia in albino wistar rats.Qualitative & quantitative estimation was also performed. Total phenol & flavonoid content was found to be 0.374 mg/100mg and 0.685 mg/100mg of dried extract. Hyperthermia was induced by subcutaneous injection of 20% (w/v) aqueous suspension of brewer's yeast. Paracetamol was used as positive control.Rectal temperature of albino rats was verified immediately before the administration of the extracts or vehicle or paracetamol and yet again after 18 hours. Animals were divided into four groups with six animals in each group. Group Group III&Group IV were given Hydroalcoholic extract of Aervalanata at dose of 250 mg/kg & 350mg/kg respectively. Results showed that the hydroalcoholic extract of Aervalanataat dose of 205 mg/kg & 350 mg/kg found to have rectal temperature as 38.19± 0.23 and 37.82± 0.18 degree Celsius respectively. These results are apparently close to the effect of standard paracetamol at dose of 150 mg/kg which was found to be 37.62±0 .11 degree Celsius. So, it is evident that Aervalanataleaves have antipyretic potential close to that of standard drug paracetamol.

Keywords: Anti-Pyretic, Aervalanata, Herbal medicine, Fever