FORMULATION, DEVELOPMENT AND EVALUATION OF BUCCAL MUCOADHESIVE TABLETS OF NARATRIPTAN
Abstract
Naratriptan completely absorbed following oral administration. The mean oral absolute bioavailability of the tablet is about 60%. This clearly indicates that Naratriptan have first pass metabolism problem. The aim of present work to formulate and characterize buccal mucoadhesive tablets of Naratriptan. Buccal tablets of Naratriptan using HPMC K4, Carbopol 934 and Na Alginate prepared by direct compression method were found to be good without chipping, capping and sticking. The drug content was uniform in all the formulations of tablets prepared. Low values of standard deviations indicate uniform distribution of drugs within the matrices. The drug polymer ration influenced the release of drug from the formulations. An increase in polymer decreased the drug release. Formulation F4 with drug polymer (HPMC K4, carbopol and Na Alginate) has shown promising results as per USP test II requirements.
Key words: Naratriptan, Buccal mucoadhesive tablets, Formulation, Evaluation
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