PHYTOCHEMICAL SCREENING AND ASSESSMENT OF ADHATODA VASICA (LEAF) FOR ANTIASTHMATIC ACTIVITY
Abstract
In present study, the bronchodilating effect was evaluated by observing the effect of ethanolic extract of Adhatoda vasica on acetylcholine and histamine aerosol induced broncho-constriction in guinea pigs. Significant increase in preconvulsion time was observed the due to pretreatment with Adhatoda vasica when the guinea pigs were exposed to either Ach or histamine aerosol. The bronchodilating effect of Adhatoda vasica was comparable to ketotifen. It has been reported that Albizzia lebbeck and Ocimum sanctum, which are well known anti-asthmatic herbal drugs have similar mechanism of action. Spasmolytic effect of Adhatoda vasica was also evaluated by observing the effect of their ethanolic extract on histamine and Ach induced contractions of guinea pig ileum. Adhatoda vasica was found to be dose dependently inhibited ileum contractions induced by histamine and Ach. These effects of Adhatoda vasica support the improvement in the symptoms and lung function parameters of asthmatic subjects. The possible mechanism of action may be blocked of H2 and Ach receptors leading to inability of smooth muscle to respond to respond to histamine and Ach induced spasm leading to inhibition of bronco-constriction.
On the basis of all the studies we conclude that this plant has potential activity in petroleum extracts for anti-microbial and ethanolic extracts showed higher activity for analgesic, anti-inflammatory and anti-asthmatic activity.
Key words: Adhatoda Vasica, Antiasthamiatic, Asthama
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