Synthesis and biological evaluation of amino acid conjugates of tolmetin
Abstract
Synthesis and biological evaluation of amino acid conjugates of tolmetin was carried out to improve pharmacokinetic properties and to minimize undesirable side effect of ulcer genesis. Hydrolysis studies follow first order kinetics. The quantitative structure property relationship study reveals that the rate of hydrolysis of the compounds is inversely related to partition coefficient values. The study of acute and chronic anti-inflammatory and ulcerogenic activity gave statistically significant results and it concluded that the compounds minimize the gastric side effects of tolmetin remarkably.References
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