FORMULATION AND EVALUATION OF METOPROLOL TARTRATE NASAL MUCOADHESIVE MICROSPHERES

Authors

  • Adidev Bharti School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhinagar, Bhopal, India.
  • Rashmi Dahima School of Pharmacy, Devi Ahilya Vishwavidyalaya, Ring Road, Indore, India.

Abstract

Solid biodegradable mucoadhesive microspheres incorporating a drug dispersed or dissolved throughout particle matrix have the potential for the controlled release of the drug. Solid biodegradable mucoadhesive microspheres of chitosan containing metoprolol tartrate were prepared by ionic precipitation method. The aim of present work is to provide quick relief and sustained action of drug for prolong period of time by administration through nasal route as suspension
which is beneficial over conventional e teric coated tablet system because it protect the drug from gastric environment and releases drug in systemic circulation at controlled rate. The effects of different factors (chitosan concentraion, acetic acid concentration, stirring rate, gluteraldehyde concentration and tween 80 concentration) on microsphere size and encapsulation efficiency were studied. The prepared microspheres were evaluated for particle size distribution, surface morphology and entrapment efficiency. Maximum entrapment was found to be 94.19±0.015 %. The maximum release was 97.88±0.02 % within 18 hr for optimized formulation in phosphate buffer solution (pH 7.0) which shows sustained release of dosage form. So microsphere of chitosan can be successfully prepared and delivered by nasal route

References

Cupp M. Alternatives for Metoprolol Succinate, Pharmacist's Letter / Prescriber's Letter 2009; 25 (250302).

Carlsson, edited by Bo, Technological systems and industrial dynamics,Panacea Journal of Pharmacy and Pharmaceutical Sciences 2014:3(4);125-132 Page | 132 Dordrecht: Kluwer Academic. 1997: 106.

Geffner DL, Hershman JM. β-Adrenergic blockade for the treatment of hyperthyroidism, The American Journal of Medicine. 1992;93(1): 61–8.

Shahidi F, Synowiecki J. Isolation and characterization of nutrients and value-added products from snow crab (Chionoecetes opilio) and shrimp (Pandalus borealis) processing discards, J of Agri & Food Chem. 1991;39(8):1527–32.

Agnihotri S, Mallikarjuna A, Nadagouda N, Aminabhavi TM. Recent advances on chitosan-based micro- and nanoparticles in drug delivery, J of Cont Rel. 2004;100 (1):5–28.

Sadigh-Eteghad S, Talebi M, Farhoudi M, Mahmoudi J, Reyhani B. Effects of Levodopa loaded chitosan nanoparticles on cell viability and caspase-3 expression in PC12 neural like cells, Neurosciences, 2009;18(3):281–283.

Berthold A, Cremer K, Kreuter J. Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs. J. Control Rel. 1996; 39:17-25.

Krisnamoorthy R, Mitra AK, Mucoadhesive polymers inocular drug delivery, in: Ophthalmic Drug Delivery

Systems, Marcel Dekker, New York, 1993: 199–221.

Junior AA, Matos J.R. Thermal behavior and stability of biodegradable spray-dried microparticles containing triamcinolone, Int. J. Pharm. 2009;368:45–55.

Gavini E, Hegge AB, Nasal administration of Carbamazepine using Chitosan microspheres: In vitro/in vivo studies, Int. J. of Pharm. 2006;307:9–15.

Jameela SR, Kumary TV, Lal AV, Jayakrishnan A. Progesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system. J. Control Rel. 1998;52:17-24.

Dini E, Alexandridou S, Kiparissides C. Synthesis and characterization of cross-linked chitosan microspheres for drug delivery applications. J. Microencapsul. 2003;20:375-385.

Shiraishi S, Arahira M, Imai T et al. Enhancement of dissolution rates of several drugs by low-molecular weight chitosan and alginate. Chem. Pharm. Bull. 1990;38:185-187.

Lohiya NK, Pathak N, Mishra PK, Manivannan B. Contraceptive evaluation and toxicological study of aqueous extract of the seeds of Carica papaya in male rabbits. J Ethnopharmacol2000;70:17-27

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Published

2014-12-31

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Original Research Article