Inhibition of acetylcholinesterase and NADH oxidase by Acacia farnesiana
Abstract
Physiological role of NADH oxidase is to reduce oxygen and to catalyse different reactions in the living system. Acetylcholinesterase catalyzes the hydrolysis of the neurotransmitter acetylcholine and termination of the nerve impulse in cholinergic synapses. Absence of evidence on acetylcholinesterase and NADH oxidase inhibitory activity of Acacia farnesiana let us embark on this study with an aim to scientifically prove the traditional claim of this plant. Acetylcholinesterase and NADH oxidase inhibitory activity was determined using in vitro methods. Results show that the methanolic extract of areal parts of Acacia farnesiana plant exhibit significant acetylcholinesterase and NADH oxidase inhibitory activity. The AChE inhibitory and NADH oxidase inhibitory activity of this plant in this study make it an important target for the isolation and characterization of the phytocompounds responsible for this biological activity.References
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