DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCH OF CURCUMIN FOR RHEUMATOID ARTHRITIS
Abstract
Conventional drug delivery system has many problems so bulk of research has now shifted from synthetic drugs to herbal drugs. This is possible because of the vast variety of bioactive molecules in the plants and their higher safety margin. This present study is focused on the use of curcumin, the active constituent of Curcuma longa (haldi), belonging to family Zingiberaceae as an antiinflammatory agent against rheumatoid arthritis. The main objective of present work was to develop the transdermal patch of curcumin using different polymer blends so that minimize the side effects and maximize the therapeutic efficacy. The formulations were also evaluated for weight variation, drug content, thickness, moisture content, folding endurance, in vitro drug release, flux, stability studies etc., shows satisfactory results.
References
Arora, P., Mukherjee, B.; 2002. Design, development, physicochemical and in-vitro, in-vivo evaluation of transdermal patches containing diclofenac diethyl ammonium salt, J Pharm Sci. Vol. 91(9); 2078-2088.
Banerjee, K.R., Bandyopadhyay, U., Chattopadhyay, I.; 2004. Turmeric and
Panacea Journal of Pharmacy and Pharmaceutical Sciences 2015:3(4);108-120
International Journal
curcumin : Biological actions and medicinal applications. Current Science, Vol.87; 44-53. 3. Bodmeire, R.; 1999. Mathiowitz, E., Eds., Encyclopedia of Controlled Drug Delivery, Vol.2, John Wiley &sons, inc; 665-671. 4. Buhler, V.; 2005. Excipients for Pharmaceuticals - Povidone, Crospovidone and Copovidone. Berlin, Heidelberg, New York: Springer; 1–254. 5. Chien, Y.W.; 1992. Novel drug delivery systems, Drugs and the Pharmaceutical Sciences, Vol.50, Marcel Dekker, New York; 139-196. 6. Cradock, J.C., Palimer, A., Morton, F.S.S. and Lund, W.; 1986. Handbook of Pharmaceutical Excipients, Published by American Pharmaceutical Association, Washington, DC.; 111-112. 7. Fischer, F., Bauer, S.; 2009. Polyvinylpyrrolidone. Ein Tausendsassa in der Chemie. Chemie in unserer Zeit. Vol.43 (6); 376–383. 8. Gadekar, R., Thakur, G.S., Kumar, M., Saurabh, A.; 2012. Study of formulation, characterization and wound healing potential of transdermal patch of curcumin. Asian J Pharm Clin Res. Vol.5, Suppl 4; 225-230.
Gupta, R., Bajpai, M., Bhattacharya, A.; 2008. Formulation and in-vitro evaluation of transdermal drug delivery system of tizanidine hydrochloride. J of Pharm Res. Vol.7 (4); 208-213. 10. Haaf, F., Sanner, A., and Straub, F.; 1985. Polymers of N-Vinylpyrrolidone: Synthesis, Characterization and Uses. Polymer Journal. Vol.17 (1); 143–152. 11. Hadgraft, J.; 2001. Modulation of the barrier function of the skin. Skin pharmacology and applied skin physiology, 14; 72-81. 12. Indian Pharmacopoeia; 2007. Government of India ministry of health and family welfare. The Controller of Publication, Delhi; Vol.1; 2041. 13. Jain, N.K.; 1997. Controlled and novel drug delivery. 1st ed., CBS publishers & distributors; 100-127. 14. Jamakandi, V.G., Mulla, J.S., Vinay, B.L., Shivkumar, H.N.; 2009. Formulation, Characterization, and evaluation of matrix-type transdermal patches of a model antihypertensive drug. Asian J pharm,3; 59-65. 15. Kydonieus, A.; 1992. Treatise on Controlled Drug Delivery, Marcel Dekker, inc, New York; 341-415. 16. Murthy, T.E.G.K., Ramana, B.V., Kishore, B.M.; 2008. Influence of polymers on the release of carvedilol from transdermal films. Indian Drugs. Vol.45 (12); 970-974.
Patel, N., Patel, N.,Patel, R.; 2009. Design and evaluation of transdermal drug delivery system for curcumin as an anti inflammatory drug, Drug development and industrial
Panacea Journal of Pharmacy and Pharmaceutical Sciences 2015:3(4);108-120
International Journal
pharmacy.; 35, 234-242. 18. Purohit, A.P., Gupta, P.K., Verma, M.; 2009. Development of transdermal drug dosage formulation for the anti – rheumatic ayurvedic medicinal plants. Ancient Sci Life; 11,66-9. 19. Ranade, S.Y., Gaud, R.S.; 2013. Current strategies in herbal drug delivery for arthritis. International Journal of Pharmaceutical Science. Vol.4(10); 3785-3790. 20. Rao, P.R., Diwan, P.V.; 1996. Drug diffusion from cellulose acetate-polyvinyl pyrrolidone free films for transdermal administration. Ind J Pharm Sci. Vol.58 (6); 246-250. 21. Tripathi, K.D.; 2003. Essentials of medical pharmacology. 5th ed., Published by jaypee brother’s medical publisher’s pvt. Ltd., New Delhi; 167-184. 22. Vishwakarma, A.K., Maurya, O.P., Srivastava, D.; 2012. Formulation and evaluation of transdermal patch containing turmeric oil. International J of Pharmacy & Pharm Sci. Vol.4 (5); 358-361.
