OSTEOPOROSIS AND ITS MANAGEMENT: A TIMELY UPDATE
Abstract
The National Institutes of Health defines osteoporosis as a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. However, currently there is no definition that is agreeable to both medical and scientific communities and its etiology is poorly understood. It is within this framework that the pharmaceutical industry is trying to develop new treatments for the so-called silent epidemic. This review article describes the osteoporosis as a disease and look forward for the update in its management.References
and safety of ibandronate given by intravenous injection once every 3 months. Bone 34:881–9. 47. Epstein, S., Delmas, P.D., Emkey, R. et al. (2006). Oral ibandronate in the management of postmenopausal osteoporosis: Reviewof upper gastrointestinal safety. Maturitas 54:1–10. 48. Neer, R.M., Arnaud, C.D., Zanchetta, J.R. et al. (2001). Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344:1434–41. 49. Rubin, M.R., Cosman, F., Cosman, F. et al. (2002). The anabolic effects of parathyroid hormone. Osteoporos Int 13:267–77. 50. Jiang, Y., Zhao, J.J., Mitlak, B.H. et al. (2003). Recombinant human parathyroid hormone (1–34) [Teriparatide] improves both cortical and cancellous bone structure. J Bone Miner Res 18:1932–41. 51. Ettinger, B., San Martin, J., Crans, G. et al. (2004). Differential effects of Teriparatide on BMD after treatment with raloxifene or alendronate. J Bone Miner Res 19:745–51. 52. Lane, N.E., Sanchez, S., Modin, G.W. et al. (1998). Parathyroid hormone treatment can reverse corticosteroid-induced osteoporosis. Results of a randomized controlled clinical trial. J Clin Invest 102:1627–33. 53. Orwoll, E.S., Scheele, W.H., Paul, S. et al. (2003). The effect of teriparatide [Human Parathyroid Hormone (1–34)] therapy on bone density in men with osteoporosis. J Bone Miner Res 18:9–17. 54. Marie, P.J., Ammann, P., Boivin, G. et al. (2001). Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tiss Int 69:121–9.
Panacea Journal of Pharmacy and Pharmaceutical Sciences 2014:3(1); 01-16
Marie, P.J. (2005). Strontium ranelate: a novel mode of action optimizing bone formation and resorption. Osteoporos Int 16:S7–S10. 56. Nielsen, S.P., Slosman, D., Sorensen, O.H. et al. (1999). Influence of strontium on bone mineral density and bone mineral content measurements by dual X-ray absorptiometry. J Clin Densitom 2:371–9. 57. Meunier, P.J., Roux, C., Seeman, E. et al. (2004). The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350:459–68. 58. Reginster, J.Y., Seeman, E., DeVernejoul, M.C. et al. (2005). Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausalwomen with osteoporosis: treatment of peripheral osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90:2816 22. 59. Roux, C., Reginster, J.-Y., Fechtenbaum, J. et al. (2006). Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors. J Bone Miner Res 21:536–42. 60. Committee for Proprietary Medicinal Products (CPMAP). European Public Assessment Report. Protelos: scientific discussion [online] http://www.emea.eu.int/ humandocs/PDFs/EPAR/protelos/121604en6.pdf (accessed 18 April 2006). 61. Heaney, R.P. (2000). Calcium, dairy products and osteoporosis. J Am Coll Nutr 19:83S–99. 62. Dawson-Hughes, B., Harris, S.S., Krall, E.A. et al. (1997). Effect of calcium and vitamin D supplementation on bo ne density in men and women 65 years of age or older. N Engl J Med 337:670–6. 63. Cumming, R.G. and Nevitt, M.C. (1997). Calcium for prevention of osteoporotic fractures in postmenopausal women. J Bone Miner Res 12:1321–9. 64. Department of Health (1998). Nutrition and bone health: with particular reference to calcium and vitaminD. Report on Health and Social Subjects, 49. London: Department of Health. 65. Porthouse, J., Cockayne, S., King, C. et al. (2005). Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ 330:1003–6. 66. The Record Trial Group (2005). Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365:1621–8. 67. Jackson, R.D., LaCroix, A.Z., Gass, M. et al. (2006). Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354:669–83. 68. Michaelsson, K., Melhus, H., Bellocco, R. et al. (2003). Dietary calcium and vitamin D intake in relation to osteoporotic fracture risk. Bone 32:694–703. 69. Avenell, A., Gillespie, W., Gillespie, L. et al. (2005). Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. The Cochrane Database of Systematic Reviews Issue 3. CD000227. 70. Prince, R.L., Devine, A., Dhaliwal, S.S. et al. (2006). Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double blind, placebo controlled trial in elderly women. Arch Intern Med 166:869–75. 71. Brennan, J., Johansen, A., Butler, J. et al. (2003). Place of residence and risk of fracture in older people: a population-based study of over 65-year-olds in Cardiff. Osteoporos Int 14:515–19. 72. Cali, C.M. and Kiel, D.P. (1995). An epidemiologic study of fall-related fractures among institutionalized older people. J Am Geriatr Soc 43:1336–40. 73. Chapuy, M.C., Arlot, M.E., Duboeuf, F. et al. (1992). Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 372:1637–42. 74. Chapuy, M.C., Arlot, M.E., Delmans, P.D. et al. (1994). Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ 308:1081–2. 75. Lilliu, H., Pamphile, R., Chapuy, M.-C. et al. (2003). Calcium-vitamin D3 supplementation is cost-effective in hip fractures prevention. Maturitas 44:299–305. 76. Lips, P., Graafmans, W.C., Ooms, M.E. et al. (1996). Vitamin D supplementation and fracture incidence in elderly persons: a randomized, placebo-controlled clinical trial. Ann Intern Med 124:400–6. 77. Flicker, L., MacInnis, R.J., Stein, M.S. et al. (2005). Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. J Am Geriatr Soc 53:1881–8. 78. Bischoff-Ferrari, H.A., Willett, W.C., Wong, J.B. et al. (2005). Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 293:2257–64. 79. Dawson-Hughes, B., Heaney, R.P., Holick, M.F. et al. (2005). Estimates of optimal vitamin D status. Osteoporos Int 16:713–16. 80. MacLaughlin, J. and Holick, M.F. (1985). Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76:1536–8. 81. Holick, M.F., Siris, E.S., Binkley, N. et al. (2005). Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab 90:3215–24. 82. Simonelli, C., Weiss, T.W., Morancey, J. et al. (2005). Prevalence of vitamin D inadequacy in a minimal trauma fracture population. Curr Med Res Opin 21:1069–74. 83. Seton, M., Jackson, V., Lasser, K.E. et al. (2005). Low 25-hydroxyvitamin D and osteopenia are prevalent in persons _ 55 yr with fracture at any site: a prospective, Current Therapies for Osteoporosis 209 observational study of persons fracturing in the community. J Clin Densitom
Panacea Journal of Pharmacy and Pharmaceutical Sciences 2014:3(1); 01-16
:454–60. 84. Dixon, T., Mitchell, P., Beringer, T. et al. (2006). An overview of the prevalence of 25-hydroxy-vitamin D inadequacy amongst elderly patients with or without fragility fracture in the United Kingdom. Curr Med Res Opin 22:405–15. 85. Bischoff-Ferrari, H.A., Orav, E.J. and Dawson-Hughes, B. (2006). Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Arch Intern Med 166:424–30. 86. Youm, T., Koval, K.J. and Kummer, F.J., Zuckerman, J.D. (1999). Do all hip fractures result from a fall? Am J Orthop 28:190–4. 87. Royal College of Physicians and the Bone and Tooth Society of Great Britain (2000). Osteoporosis. Clinical guidelines for prevention and treatment. Update on pharmacological interventions and an algorithm for management. London: Royal College of Physicians. 88. Scottish Intercollegiate Guidelines Network (2003). Management of osteoporosis: National clinical guideline 71. http://www.sign.ac.uk/guidelines/fulltext/71/index.html (accessed 7 April 2006). 89. Department of Health (2001). National Service Framework for Older People. London: Department of Health. 90. Tilyard, M.W., Spears, G.F., Thomson, J. et al. (1992). Treatment of postmenopausal osteoporosis with calcitriol or calcium. N Engl J Med 326:357–62.
National Institute for Health and Clinical Excellence (2005). Bisphosphonates (alendronate, etidronate, risedronate), selective oestrogen receptor modulators (raloxifene) and parathyroid hormone (teriparatide) for the secondary prevention of osteoporotic fragility fractures in postmenopausal women. Technology appraisal guidance 87. London: NICE. Available at http://www.nice.org.uk/page=aspx?o=TA087guidance accessed 23/11/06 92. Tinetti, M.E., Speechley, M. and Ginter, S.F. (1988). Risk factors for falls among elderly persons living in the community. N Engl J Med 319:1701–7. 93. Pluijm, S., Smit, J., Tromp, E. et al. (2006). A risk profile for identifying communitydwelling elderly with a high risk of recurrent falling: results of a 3-year prospective study. Osteoporos Int 17:417–25. 94. Geusens, P., Autier, P., Boonen, S. et al. (2002). The relationship among history of falls, osteoporosis, and fractures in postmenopausal women. Arch Phys Med Rehabil 83:903–6. 95. Chang, J.T., Morton, S.C., Rubenstein, L.Z. et al. (2004). Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials. BMJ 328:680. 96. Gillespie, L.D., Gillespie, W.J., Robertson, M.C. et al. (2003). Interventions for preventing falls in elderly people. The Cochrane Database of Systematic Reviews Issue 4. CD000340. 97. Feldstein, A., Elmer, P., Nichols, G. et al. (2005). Practice patterns in patients at risk for glucocorticoid-induced osteoporosis. Osteoporos Int 16:2168–74. 98. Aspray, T.J., Stevenson, P., Abdy, S.E. et al. (2006). Low bone mineral density measurements in care home residents—a treatable cause of fractures. Age Ageing 35:37–41.
