PHARMACOLOGICAL EVALUATION OF NANOEMULSION OF THE SEED EXTRACT OF CARICA PAPAYA FOR MALE ORAL CONTRACEPTIVE ACTION IN MICE
Abstract
Carica papaya Linn. is the most widely cultivated and best known species serve as contraceptive as reported in ancient literature. In aim of the present study is to demonstrate the male oral contraceptive efficacy of seed oil of Carica papaya Linn. In vivo evaluation and comparison between crude extract and nanoemulsion for oral male contraceptive activity were carried out on Swiss albino mice including MTT cell cytotoxicity assay. From this study it has been demonstrated that Carica papaya seed oil possesses reversible male contraceptive potential, when administered orally. Even though the crude seed oil is more effective contraceptive the nanoemulsion can be considered a better contraceptive as it does not cause any behavior changes, morbidity and tissue toxicity as well as easily administered and delivered. Hence papaya seed oil can be utilized for delivery of contraceptive action in males.References
Bagros M. Research on the coagulation of cervical secretion envisaged as contraceptive process. Therapie 1979;34:523-527.
Bingel AS, Benoit PS. Oral contraceptives: therapeutics versus adverse reactions, with an outlook for the future I. J Pharm Sci 1973;62:179-200.
Chinoy NJ, George SM. Induction of functional sterility in male rats by low dose Carica papaya seed extract treatment. Acta Eur Fert1983;14:425-429.
Chinoy NJ, D'Souza JM, Padman P. Contraceptive efficacy of Carica papaya seed extract in male mice (Mus musculus). Phytother Res 1995;9:30-36.
Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: Publications and Information Directorate, Council of Scientific and Industrial Research; 1956, p. 256-257.
Deshpande VY, Mendulkar KN, Sadre NL. Male antifertility activity of Azadirachta Indica in mice. J Postgrad Med 198026:167-169.
Dhawan BN, Dubey MP, Mehrotra BN, Tandon JS. Screening of Indian plants for biological activity: Part IX. Indian J Exp Biol 1982;18:594-602.
Lohiya NK, Goyal RB, Jayaprakash D, Ansari AS, Sharma S. Antifertility effects of aqueous extract of Carica papaya seeds in male rats. Planta Med 1994;60:400-405.
Lohiya NK, Pathak N, Mishra PK, Manivannan B. Contraceptive evaluation and toxicological study of aqueous extract of the seeds of Carica papaya in male rabbits. J Ethnopharmacol 2000;70:17-27.
