REVIEW ON: DEVELOPMENT OF NOVEL HERBAL SYSTEM FOR RHEUMATOID ARTHRITIS
Abstract
Rheumatoid arthritis is a major inflammatory disease which is caused due uric acid crystal formation in the joints which causes inflammation. Rheumatoid arthritis is both an extravascular immune complex disease and a disorder of cell mediated immunity leads to chronic inflammation, granuloma formation and joint destruction. Conventional drugs form a major line treatment in management of rheumatoid arthritis includes analgesics, non steroidal anti inflammatory drugs, disease modifying antirheumatic drugs, corticosteroids. Since conventional drug delivery has many problems such as poor drug concentration, undesirable side effects and poor efficiency, which creates a need for development of novel drug delivery systems which could overcome these problems. The present investigation was aimed to formulate transdermal system possessing anti-inflammatory activity which would bypass the first pass metabolism and maintain a steady serum concentration. This experiment is one of the first few attempts to utilize ayurvedic drugs through transdermal drug delivery system for anti rheumatic activity.
References
Banerjee KR, Bandyopadhyay U, Chattopadhyay I. Turmeric and curcumin: Biological actions and medicinal applications. Current Science 2004;87:44-53.
Chien YW. Novel drug delivery systems, Drugs and the Pharmaceutical Sciences. Vol.50.Marcel Dekker, New York 1992:139 196.
Hadgraft J. Modulation of the barrier function of the skin. Skin pharmacology and applied skin physiology 2001;14:72-81.
Jain NK. Controlled and novel drug delivery. 1st ed., CBS publishers and distributors 1997:100-127.
Kydonieus A. Treatise on Controlled Drug Delivery, Marcel Dekker, New York 1992:341-415.
Patel N, Patel N, Patel R. Design and evaluation of transdermal drug delivery system for curcumin as an anti inflammatory drug, Drug development and industrial pharmacy 2009;35:234-242.
Purohit AP, Gupta PK, Verma M. Development of transdermal drug dosage formulation for the anti – rheumatic ayurvedic medicinal plants. Ancient Sci Life; 2009:11,66-9.
Srimol RC, Dhawan BN. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol 1973;25:447–452.
Tripathi KD. Essentials of medical pharmacology. 5th ed., Published by jaypee brother’s medical publisher’s Pvt Ltd, New Delhi; 2003:167-184.
Wilkes GL, Nguyen AL, Wildnauer R. Structure-property relations of human and neonatal rat stratum corneum. I. Thermal stability of the crystalline lipid structure as studied by X-ray diffraction and differential thermal analysis. Biochim Biophys Acta; 1973;304:265-75.
