FORMULATION AND EVALUATION OF MEFENAMIC ACID GEL FOR TOPICAL DELIVERY

Authors

  • Nehal Sandanshi School of Pharmacy, Devi Ahilya Vishwavidyalaya, Taksashila Campus, Khandwa Road, Indore-452001, M.P., India
  • Devashish Rathore School of Pharmacy, Devi Ahilya Vishwavidyalaya, Taksashila Campus, Khandwa Road, Indore-452001, M.P., India
  • Rashmi Dahima School of Pharmacy, Devi Ahilya Vishwavidyalaya, Taksashila Campus, Khandwa Road, Indore-452001, M.P., India

Abstract

Objective: Mefenamic acid is an anthranilic acid derivative and is used to treat pain, including menstrual pain. Wide choice of vehicles ranging from solids to semisolids form has been used for skin care and topical treatment of dermatological disease. The objective of the study was to prepare gel of Mefenamic acid, a NSAID, using Carbopol 940, Carbopol 934, mixture of Carbopol 934 and 940 and Carboxymethylcellulose (CMC) as a gelling agent.

Methodology: Gel formulations were prepared and characterized for appearance, pH determination, spreadability, homogeneity and grittiness, extrudability, drug content and release.

Results:  The drug content was found to be 90.68%, 92.31% and 91.54% for Carbopol 940, Carbopol 934 and mixture of Carbopol 940 & 934 respectively. The sustained releases from all the prepared gel formulation were observed. The cumulative percent releases at 120 minutes were found to be 96.03%, 82.99% and 92.43% for Carbopol 940, Carbopol 934 and mixture of Carbopol 940 and 934 respectively.

Conclusion: The oral use of Mefenamic acid is not much recommended as it has many side effects. Commercially Mefenamic acid  topical gel preparation are not available in the market, thus this formulation is made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage.

 

Keywords: Gel, Mefenamic acid, Carbopol 940, Carbopol 934, Topical drug delivery

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How to cite this article:

Nehal Sandanshi, Devashish Rathore, Rashmi Dahima. Formulation and evaluation of mefenamic acid gel for topical delivery; Journal of Pharmacy and Pharmaceutical Sciences 2018:7(1);719-728.

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Published

2018-03-30

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Original Research Article