INFLAMMATORY MARKER IN DIABETES MELLITUS: A CASE CONTROL STUDY IN CENTRAL INDIA
Abstract
Aim and Objective: Type 2 diabetes mellitus (T2DM) is a heterogeneous group of metabolic disorders characterized by chronic hyperglycemia. In the pathogenesis of diabetes mellitus, it is recognized that chronic low-grade inflammation plays important role. The aim of present study was to evaluate level of inflammatory marker tumor necrosis factor-α (TNF-α) and their correlation with fasting glucose level in type -2 diabetic subjects.
Material and Methods: Total 100 study subjects were divided into two groups, group A comprising 50 apparently healthy age sex matched controls and group B comprising 50 patients of diagnosed type 2 diabetic mellitus. Subjects were enrolled after applying all inclusion and exclusion criteria and written informed consent were taken.Inflammatory marker,TNF-α was estimated by enzyme linked immunosorbent assay (ELISA) method.
Results:The mean TNF-α in the control group was 5.34± 1.98pg/mlwhile in the diabetes mellitus group it was 56.90±18.15pg/ml. The difference was found to be statistically significant (p<0.05), showing a higher TNF-αin the diabetes mellitus group in comparison to the control group. There is also positive correlation between TNF-α and fasting glucose (r = 0.617, p<0.05).
Conclusion:There is increased inflammation in diabetic condition as shown by greater elevation of inflammatory marker such as TNF-α. This pathogenic factor might be helpful to a consideration of new therapeutic approach in diabetes mellitus and further development of complications.
Keywords: Diabetes mellitus, tumor necrosis factor-α (TNF-α), marker
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