FORMULATION AND CHARACTERIZATION OF LIPOSPHERES OF BCS CLASS II DRUG LANSOPRAZOLE

Abstract

This study focuses on the formulation and characterization of Lansoprazole-loaded lipospheres to enhance their solubility and bioavailability. Lipospheres were prepared using a melt dispersion technique, with varying ratios of lipid core components and surfactants. The formulations were evaluated for percentage yield, drug entrapment efficiency, particle size, zeta potential, flow properties, and drug release kinetics. Among the formulations tested, F2 exhibited the highest percentage yield (85.45% ± 0.32) and drug entrapment efficiency (84.65% ± 0.36). Microscopic analysis confirmed the spherical morphology and uniform distribution of lipospheres in F2, with a mean particle size of 156.30 nm. Zeta potential measurements indicated good stability and flow properties were suitable for further processing. The drug release profile of F2 followed First Order kinetics, demonstrating sustained release over 12 hours.

Keywords: Lansoprazole, lipospheres, melt dispersion technique, drug delivery, bioavailability, particle size, zeta potential, sustained release, first order kinetics.