FORMULATION AND CHARACTERIZATION OF ANTI-FUNGAL ETHOSOMAL GEL FOR EFFECTIVE TOPICAL FUNGAL TREATMENT

Abstract

This study focuses on the formulation and characterization of an anti-fungal ethosomal gel containing Tioconazole for effective topical treatment. Ethosomal formulations (F1-F6) were examined microscopically, revealing uniform vesicle sizes ranging from 159.85 to 220.32 µm across different formulations. Formulations F4 and F6 exhibited high entrapment efficiencies of 74.65%, indicating effective encapsulation of Tioconazole within the ethosomal vesicles. Gel formulations (EF1-EF3) demonstrated excellent homogeneity (+++), texture, and spreadability (9.23-12.32 gm.cm/sec), with good extrudability and washability. pH values (6.78-6.92) were suitable for topical application, ensuring skin compatibility. Viscosity (2985-3365 cps) and high assay percentages (97.36%-99.15%) confirmed formulation consistency and potency. The cumulative drug release profile from EF2 showed sustained release kinetics over 10 hours, reaching 96.65% drug release. Regression analysis (Zero order, First order, and Pappas plot) of EF2 indicated high correlation coefficients (R² = 0.9281-0.9729), supporting predictable and controlled drug release. Overall, this ethosomal gel formulation demonstrates potential for enhanced therapeutic efficacy in topical fungal treatment.

Key Words: Ethosomal gel, Tioconazole, anti-fungal treatment, vesicle size, entrapment efficiency, sustained release, topical application, formulation characterization