CURRENT REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM

Abstract

Transdermal drug delivery systems (TDDS) have gained significant attention as a non-invasive method for administering pharmaceuticals through the skin, offering advantages over traditional oral and injectable routes. This review provides a comprehensive overview of current advancements in TDDS, focusing on the technology, formulations, and applications. TDDS facilitate controlled and sustained release of drugs, enhance patient compliance, and improve therapeutic efficacy by bypassing the gastrointestinal tract and first-pass metabolism. Key technologies discussed include adhesive patches, microneedle systems, and iontophoresis. The review also addresses challenges such as skin permeability, drug selection, and formulation stability. Emerging innovations in TDDS, such as smart patches and nano-based carriers, are explored for their potential to further enhance drug delivery efficiency and patient outcomes. Overall, TDDS represents a promising approach for modern drug delivery, with ongoing research aimed at overcoming existing limitations and expanding its clinical applications.

Keywords: Transdermal drug delivery systems, adhesive patches, microneedles, iontophoresis, drug permeability, smart patches, nano-based carriers.