FORMULATION AND CHARACTERIZATION OF PARENTRAL DOSAGE FORM FOR POORLY SOLUBLE DRUGS
Abstract
The parenteral administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. But parenteral route offers rapid onset of action with rapid declines of systemic drug Level. For the sake of effective treatment it is often desirable to maintain systemic drug levels within the therapeutically effective concentration range for as long as treatment calls for. It requires frequent injection, which ultimately leads to patient discomfort. For this Reason, drug delivery system which can reduce total number of injection throughout the effective treatment, improve patient compliance as well as Pharmacoeconomic. These biodegradable Injectable drug delivery system offer attractive opportunities for protein delivery and could possibly extend patent life of protein drugs. This article explores various prolonged release parenteral drug delivery system and their strategies of preparation, their potential benefits/drawbacks and in-vitro testing methods.References
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