ROLE OF PRAKRITI IN HEALTH, DISEASE, AND PERSONALIZED THERAPEUTICS: AN INTEGRATIVE REVIEW BASED ON AYURVEDIC PRINCIPLES

Abstract

Background: Ayurveda, the ancient Indian system of medicine, emphasizes individual-centric healthcare through the concept of Prakriti (body constitution), which reflects the inherent physiological, psychological, and metabolic makeup of an individual. Determined at the time of conception by the dominance of the three Doshas (Vata, Pitta, and Kapha) and influenced by genetic and environmental factors, Prakriti plays a critical role in predicting disease susceptibility, physiological characteristics, and therapeutic responses. Materials and Methods: A thorough review of classical Ayurvedic texts including Charaka Samhita, Sushruta Samhita, and contemporary research articles, journals, government reports like the "Desh Ka Prakriti Parikshan Abhiyan", and recent clinical studies was conducted. Relevant information was compiled to explore the determinants, classifications, diagnostic tools, and clinical relevance of Prakriti in disease prevention and personalized therapeutics.

Result: The review highlights that Prakriti serves as a foundational determinant of disease predisposition, progression, and treatment outcome. Clinical studies demonstrate correlations between Prakriti and genetic markers, immune profiles, metabolic pathways, and psychological behaviours. Diagnostic tools like Nadi Vigyan and digital apps have improved Prakriti assessment accuracy. Tailored dietary, lifestyle, and therapeutic interventions based on Prakriti enhance treatment efficacy and reduce disease risk. Conclusion: Understanding Prakriti offers a practical and evidence-supported approach to predictive, preventive, and personalized medicine in Ayurveda. Integrating Prakriti assessment into modern healthcare can lead to holistic and individualized treatment plans, bridging traditional wisdom with modern biomedical research.