CRITICAL APPRAISAL OF PRAKRITI IN KRIYA SHARIR AND ITS CONTEMPORARY PHYSIOLOGICAL SIGNIFICANCE
DOI:
https://doi.org/10.22159/prl.ijayush.v15i08.2540Keywords:
Prakriti; Kriya Sharir; Tridosha; constitutional physiology; Ayurgenomics; personalized medicineAbstract
Background: Prakriti is the constitution-specific expression of the three Doshas described in Ayurveda and occupies a central position in Kriya Sharir because it explains stable inter-individual differences in normal structure, function, adaptability, disease susceptibility and response to diet, environment and therapy. Contemporary physiology increasingly recognizes comparable inter-individual heterogeneity through systems biology, metabolic phenotyping, autonomic variability, genomics, inflammatory profiles and precision medicine. A critical appraisal is therefore needed to distinguish meaningful physiological parallels from over-simplified one-to-one equivalence. Aim and Objectives To critically appraise the concept of Prakriti as described in Kriya Sharir. To explain determinants, classification and characteristic physiological features of Vata, Pitta and Kapha predominant constitutions. To relate classical constitutional observations to contemporary concepts of homeostasis, metabolism, autonomic function, thermoregulation, body composition, immunity and psychophysiology. To review selected genomic, biochemical and clinical correlates of Prakriti and identify limitations in present evidence. To highlight the relevance of Prakriti to personalized preventive physiology and precision health without making unsupported one-to-one biomedical equivalences. Materials and Methods: A structured narrative review was undertaken using classical Ayurvedic sources and selected peer-reviewed literature on Prakriti, Tridosha, constitutional physiology, Ayurgenomics and Prakriti assessment. Conceptual statements were compared with contemporary physiological observations while avoiding direct equivalence where evidence remains preliminary Results & Discussion: The most defensible contemporary interpretation is that Prakriti represents a systems-level phenotype emerging from interacting biological traits rather than a single organ, gene or biomarker. Standardized and validated assessment remains the major methodological requirement for future physiological research. Conclusion: Prakriti remains highly relevant to Kriya Sharir as an individualized model of normal physiology and adaptive capacity. Its modern significance lies in hypothesis generation for phenotyping and precision health, while clinical application should remain grounded in classical assessment and supported by stronger prospective validation.
Downloads
References
Sharma RK, Dash B. Agnivesa's Caraka Samhita: Text with English Translation and Critical Exposition Based on Cakrapani Datta's Ayurveda Dipika. Varanasi: Chowkhamba Sanskrit Series Office; 2014.
Sharma PV. Susruta Samhita with English Translation of Text and Dalhana's Commentary. Varanasi: Chaukhambha Visvabharati; 2010.
Patwardhan B, Bodeker G. Ayurvedic genomics: establishing a genetic basis for mind-body typologies. J Altern Complement Med. 2008;14(5):571-576. doi:10.1089/acm.2007.0515.
Venkatesh A, Johansson L, Sivanandan PV, Gopakumar SP, Sankaranarayanan K, Kessler CS, et al. Prakriti (constitutional typology) in Ayurveda: a critical review of Prakriti assessment tools and their scientific validity. Front Med (Lausanne). 2025;12:1656249. doi:10.3389/fmed.2025.1656249.
Murthy KRS. Vagbhata's Astanga Hrdayam: Text, English Translation, Notes, Appendix and Indices. Varanasi: Chowkhambha Krishnadas Academy; 2012.
Lad V. Textbook of Ayurveda: Fundamental Principles. Albuquerque: The Ayurvedic Press; 2002.
Tripathi B. Charaka Samhita of Agnivesha, elaborated by Charaka and Dridhabala. Varanasi: Chaukhamba Surbharati Prakashan; 2013.
Hankey A. Establishing the scientific validity of Tridosha part 1: Doshas, Subdoshas and Dosha Prakritis. Anc Sci Life. 2010;29(3):6-18.
Ghodke Y, Joshi K, Patwardhan B. Traditional medicine to modern pharmacogenomics: Ayurveda Prakriti type and CYP2C19 gene polymorphism associated with metabolic variability. Evid Based Complement Alternat Med. 2011;2011:249528. doi:10.1093/ecam/nep206.
Dey S, Pahwa P. Prakriti and its associations with metabolism, chronic diseases, and genotypes: possibilities of newborn screening and a lifetime of personalized prevention. J Ayurveda Integr Med. 2014;5(1):15-24. doi:10.4103/0975-9476.128848.
Prasher B, Negi S, Aggarwal S, Mandal AK, Sethi TP, Deshmukh SR, et al. Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda. J Transl Med. 2008;6:48. doi:10.1186/1479-5876-6-48.
Govindaraj P, Nizamuddin S, Sharath A, Jyothi V, Rotti H, Raval R, et al. Genome-wide analysis correlates Ayurveda Prakriti. Sci Rep. 2015;5:15786. doi:10.1038/srep15786.
Aggarwal S, Negi S, Jha P, Singh PK, Stobdan T, Pasha MAQ, et al. EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Proc Natl Acad Sci U S A. 2010;107(44):18961-18966. doi:10.1073/pnas.1006108107.
Mahalle NP, Kulkarni MV, Pendse NM, Naik SS. Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance. J Ayurveda Integr Med. 2012;3(3):150-157. doi:10.4103/0975-9476.100186.
Kurande VH, Waagepetersen R, Toft E, Prasad R. The basic cardiovascular responses to postural changes, exercise, and cold pressor test: do they vary in accordance with the dual constitutional types of Ayurveda? Evid Based Complement Alternat Med. 2011;2011:251850. doi:10.1093/ecam/nep176.
Dhondge RH, Nair PM, Bhatt N, Pishva P, Shelke S, Suresh J, et al. An Ayurgenomics approach: Prakriti-based drug discovery and development for personalized care. Front Pharmacol. 2022;13:866827. doi:10.3389/fphar.2022.866827.

