STUDYING THE ROLE OF HOMEOPATHY AS AN ADD-ON THERAPY IN YOUNG PATIENTS WITH TRANSFUSION DEPENDENT BETA THALASSEMIA ON IMPROVING HEALTH-RELATED QUALITY OF LIFE - AN EXPERIMENTAL UNCONTROLLED STUDY
DOI:
https://doi.org/10.5281/zenodo.21473067Abstract
Inherited disorders of haemoglobin are the commonest genetic disorders in the world and constitute a major health problem. The Thalassaemias are a group of inherited disorders of Haemoglobin production in which there is impaired synthesis of alpha or beta globin chains.Beta thalassemia major presents with severe anaemia,poor growth,skelelatal abnormalities and requires lifelong blood transfusions which further causes iron overload related complications and are fatal.
The purpose to conduct the study using Individualized Homeopathic Medicines is to see whether they improve Health Related Quality of Life ,improve parameters like Hb,Serum ferritin and reduce transfusion frequency in Thalassemia patients and this can be assessed with TranQol Questionnaire.
OBJECTIVES:Primary:.To study the role of Homoeopathy as an Add on therapy in patients with transfusion dependent Beta Thalassemia on improving health related quality of life.
Secondary:.To study the role of Homoeopathy in reducing the frequency of blood transfusion and in improving blood parameters like Hemoglobin percentage and Serum Ferritin levels in transfusion dependent Beta Thalassemia.
MATERIALS AND METHODS:20 cases of Thalasssemia Major from age group 10-24 were selected for an experimental uncontrolled study from opd,IPD,camps,Thalassemia centres.Medicines were prescribed after repertorization,based on totality of symptoms and final differntiation from materia medica.Data was analysed using Paired t test for the Quality of life scores and using Wilcoxon sign rank test for parameters like Hb,serum ferritin and trasfusion cycles.
RESULT:The P value was significant at 95 % confidence interval for the improvement in Quality of life of Thalassemia patients using the paired t test.Homoeopathy played a role in reducing the frequency of blood transfusion and improving the blood parameters like Haemoglobin percentage and Serum Ferritin levels in transfusion dependent Beta thalassemia based on Wilcoxon Sign rank test Statistics.
CONCLUSION:This study provides preliminary evidence that Homoeopathy as an add on therapy may offer benefits in managing thalassemia symptoms,including improvement in Quality of life and reduction in transfusion needs.
Downloads
References
de Gruchy GC. De Gruchy's Clinical Haematology in Medical Practice. 5th ed. Oxford: Oxford University Press.
Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's Principles of Internal Medicine. 19th ed. Vol. 1. New York: McGraw-Hill Education.
Walker BR, Colledge NR, Ralston SH, Penman ID, editors. Davidson's Essentials of Medicine. 22nd ed. Elsevier Ltd.
Aggarwal R, et al. Thalassemia in adults: management issues. In: API Medicine Update. Vol. 31. New Delhi: Jaypee Brothers Medical Publishers; 2021.
Thalassaemia International Federation. Guidelines for the Management of Transfusion-Dependent Thalassaemia. 4th ed. Nicosia: Thalassaemia International Federation; 2021.
Dhawale ML. Principles and Practice of Homoeopathy. 10th impression. New Delhi: B. Jain Publishers.
Close S. The Genius of Homoeopathy: Lectures and Essays on Homoeopathic Philosophy. New Delhi: B. Jain Publishers.
Kawthalkar SM. Essentials of Haematology. 2nd ed. New Delhi: Jaypee Brothers Medical Publishers.
Alagappan R. Manual of Practical Medicine. 4th ed. New Delhi: Jaypee Brothers Medical Publishers. p. 358-60.
Harsh Mohan. Textbook of Pathology. 9th ed. New Delhi: Jaypee Brothers Medical Publishers Pvt. Ltd.
Michael A, et al. Thalassemia: An overview. Int J Neonatal Screen. 2019;5(16). doi:10.3390.
Klaassen RJ, et al. Introducing the TranQol: A new disease-specific quality of life measure for children and adults with thalassemia major. J Blood Disord Transfus. 2013. Available from: https://www.researchgate.net/publication/270015245
Banerjee A, et al. Efficacy of some homeopathic drugs in modulating different blood parameters in thalassemic patients: A short-term study. Available from: http://bhmch.org/images/research_pub/15549703582.%20%20%20Sukul%20arsenic%202010.pdf
Banerjee A, et al. Patients on hydroxyurea therapy? Encouraging results of a preliminary study. Available from:
http://bhmch.org/images/research_pub/15549703582.%20%20%20Sukul%20arsenic%202010.pdf
Kumar S, Khurana A, et al. Antiviral activity of Belladonna during Japanese encephalitis virus infection via inhibition of microglia activation and inflammation leading to neuronal cell survival. ACS Chem Neurosci. 2020;11(21):3683-96.
doi:10.1021/acschemneuro.0c00603.
Kar A, et al. Derivation of an empirical relation between the size of the nanoparticle and the potency of homeopathic medicines. Int J High Dilution Res. 2021;14(4):2-7. doi:10.51910/ijhdr.v14i4.804.
Dey D, Jingar P, Agrawal S, Shrivastava V, Bhattacharya A, Manhas J, et al. Symphytum officinale augments osteogenesis in human bone marrow-derived mesenchymal stem cells in vitro as they differentiate into osteoblasts. J Ethnopharmacol. 2020;248:112329. doi:10.1016/j.jep.2019.112329.
Jyothilakshmi V, Thellamudhu G, Kumar A, Khurana A, Nayak D, Kalaiselvi P. Preliminary investigation on ultra high diluted B. vulgaris in experimental urolithiasis. Homeopathy. 2013;102(3):172-8. doi:10.1016/j.homp.2013.05.004.
Sampath, Khurana A, et al. Effect of homeopathic preparations of Syzygium jambolanum and Cephalandra indica on gastrocnemius muscle of high-fat and high-fructose-induced type 2 diabetic rats. Homeopathy. 2013;102(3):160-71.
doi:10.1016/j.homp.2013.05.002.
Nayak R, Manchanda RK, et al. Effect of adjuvant homeopathy with usual care in management of thrombocytopenia due to dengue: A comparative cohort study. Homeopathy. 2019;108(3):150-7. doi:10.1055/s-0038-1676953.
Saha S, et al. Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an immuno-modulatory circuit. BMC Complement Altern Med. 2013;13(1):230. doi:10.1186/1472-6882-13-230.
National Health Mission. Guidelines for Haemoglobinopathies in India. New Delhi: Ministry of Health and Family Welfare, Government of India.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Dr. Maneesha Solanki, Dr Priyanka Shukla
This work is licensed under a Creative Commons Attribution 4.0 International License.
