PHARMACEUTICO-ANALYTICAL AND EXPERIMENTAL STUDY OF SAINDHAVA HINGUVADI GHRITA WSR TO ITS ANTIEPILEPTIC EFFECT

Abstract

Bhaishajya Kalpana is a branch of Ayurveda which deals with the preparation of many formulations. Sneha Kalpana is a unique method of preparation which coming under Bhaishajya Kalpana.Sneha Kalpana helps to utilise fat soluble and water soluble properties of drugs. Among four snehas Ghrita is the best one.It is stated as Sarvasnehottama and Samskarasyanuvartanam.The present study is concerned with the formulation Saindhava Hinguvadi ghrita which is mentioned in Charaka  Apasmara Chikitsa.In classics many ghrita preparations are mentioned under Apasmara Chikitsa.Many are not explored for its therapeutic efficacy. Till now no scientific studies have been carried out in this formulation.The aim of the studyis to scientifically establish the anti epile ptic effect of Saindhava  Hinguvadi ghrita Physicochemical analysis was also done to evaluate the study. Methodological section was divided into three parts, pharmaceutical study,analytical study, experimental study. Three samples of Saindhava Hinuvadi ghrita were prepared and assessment of sneha paka was done according to Acharya Sarangadhara.The analysis was done using parameters like Specific gravity, Loss on drying, Viscosity, Refractive index, Acid value, Iodine value, Peroxide value, Saponification value and Instrumental parameter, HPTLC were also done. Pharmaceutical study showed difference in time duration in sample Ⅰ to attain mridupaka compared to others.Percentage of yield was higher in Sample Ⅱ.Analytical study revealed as follows:-Specific gravity revealed addition of active constituants of the drugs to ghrita,was increased in all samples. Refractive index was same in all samples.Viscosity values showed decrease in all samples.LOD showed less moisture content in all samples.Results of Acid value, Iodine value and Peroxide value showed increase in unsaturation.Saponification value denotes greater percent of short chain acids in all samples.HPTLC showed the presence of active compounds in samples compared to plain ghrita.Experimental study revealed as follows:-Saindhava Hinguvadi Ghrita showed statistically nonsignificant results in experimental study.