A CONCEPTUAL OVERVIEW OF GRANULES (KHANDA KALPANA) AND ITS UTILITY FOR CLINICIANS

Abstract

Granules, rooted in the classical Ayurvedic practice of Khanda Kalpana, represent a pivotal innovation in herbal drug delivery, offering enhanced stability, palatability, and ease of administration compared to traditional forms like churna or kwatha. This review explores the historical context, preparation methods, key formulations including Haridra Khanda, Kushmanda Khanda, Shalaparni granules, and other Khanda Kalpana examples and their pharmacognostical evaluations. It elaborates on the advantages, limitations, and clinical utility of granules in managing conditions such as obesity, infertility, cognitive disorders, inflammatory diseases, allergies, and digestive disorders. Standardized through physicochemical and HPTLC analyses, granules align traditional Ayurveda with modern pharmaceutical standards, facilitating evidence-based practice and global acceptance.