Analysis of benzoic acid bulk sample using sodium saccharin as hydrotropic solubilizing agent
Abstract
In the present investigation, hydrotropic solubilization technique has
been employed to solubilize the slightly water soluble topical antifungal
drug, benzoic acid (by 2 M sodium saccharin solution), for its titrimetric
analysis. There was more than 20 fold enhancement in aqueous solubility
of benzoic acid in 2 M sodium saccharin solution as compared to the
solubility in distilled water. The hydrotropic agent did not interfere in
the analysis. The proposed method is new, simple, accurate and
reproducible. Statistical data proved the accuracy, reproducibility and
precision of the proposed method.
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