FORMULATION OF DICLOFENAC SODIUM TRANSDERMAL PATCH FOR RHEUMATOID ARTHRITIS

Neha Rathore, Sonam Mahant, Anish Chandy

Abstract


The pathogenesis of rheumatoid arthritis focused on auto antibodies and immune complexes. Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of disability. T-cell-mediated antigen-specific responses, T-cell-independent cytokine networks, and aggressive tumour-like behaviour of rheumatoid synovial have also been implicated. Based on the pathogenic mechanisms, specific therapeutic interventions can be designed to suppress synovial inflammation and joint destruction in rheumatoid arthritis. “Diclofenac sodium” is a non-steroidal anti-inflammatory drug (NSAIDs) advocated for use in painful and inflammatory rheumatic and certain non-rheumatic conditions. It is available in a number of administration forms which can be given orally, rectally, topically or intramuscularly. The main objective of this study was to prepare the optimized formulation of Diclofenac sodium transdermal patch for the treatment of Rheumatoid arthritis. This study is further aimed to analyse, concentration of drug reaching in the body and to study its effect.

KEY WORDS:

Rheumatoid arthritis, Diclofenac sodium, Transdermal patch


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