ANTI-INFLAMMATORY POTENTIAL OF α-FENCHOL AND αGURJUNENE: AN IN VITRO STUDY

Authors

  • Mithun Singh Rajput School of Pharmacy, Devi Ahilya Vishwavidyalaya, Taksashila Campus, Khandwa Road, Indore452001, M.P., India
  • Devashish Rathore School of Pharmacy, Devi Ahilya Vishwavidyalaya, Taksashila Campus, Khandwa Road, Indore452001, M.P., India
  • Rashmi Dahima School of Pharmacy, Devi Ahilya Vishwavidyalaya, Taksashila Campus, Khandwa Road, Indore452001, M.P., India

Abstract

Chronic inflammatory diseases are still one of the main health complications acknowledged globally. At present, although synthetic drugs are dominating the market, element of toxicity that these drugs entail, cannot be ruled out; hence the search for newer therapeutic strategies with lesser side effects has always been a matter of research. The present study aims to evaluate the in vitro anti-inflammatory effects of two essential oils α-Fenchol and α-Gurjunene. Methodology: In vitro anti-inflammatory activity of both the essential oils was evaluated using albumin denaturation assay. Results:  At various concentrations viz. 31.25, 62.50, 125.00, 250.00, 500.00 and 1000.00 μg/ml, α-Fenchol exhibited inhibition of protein denaturation in the range of 180-1400% and α-Gurjunene in the range of 290-360%. The present findings corroborated the anti-inflammatory property of essential oils, α-Fenchol and αGurjunene in vitro.  Conclusion: Both the essential oils possess in vitro anti-inflammatory effects, further definitive studies are necessary to ascertain the mechanisms behind their anti-inflammatory actions in vivo using suitable experimental models.   Keywords: α-Fenchol, α-Gurjunene, Anti-inflammatory, Protein denaturation

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How to cite this article:

Mithun Singh Rajput, Devashish Rathore, Rashmi Dahima. Anti-inflammatory potential of α-fenchol and α-gurjunene: an in vitro study; Panacea Journal of Pharmacy and Pharmaceutical Sciences 2018:7(3);129-135.

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Published

2018-09-30

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Original Research Article