Approach to Wound Healing

Authors

  • Mehmet Evren Okur Anadolu Univeristy, Faculty of Pharmacy, Department of Pharmacology, Eskişehir, Turkey

Abstract

Wound healing is still an unmet challenge among surgical society. As wound healing called the process of the complex and carefully regulated physiologic response to a traumatic injury. Herein, a brief review of the literature concerning the wound healing process is presented. Wound healing process can be divided into at least 3 continuous and overlapping processes: inflammatory reaction, proliferative process which leads to tissue restoration, and finally tissue remodeling. This review summarizes the current information regarding wound healing responses and explain the underlying pathophysiology.

 

References

Peng-Hui Wang, Ben-Shian Huang, Huann-Cheng Horng, Yeh CC, Chang-Ching Yeh. Wound healing. Journal of the Chinese Medical Association. 2018; 81: 94–101.

Dimitra Kiritsi, Alexander Nyström. The role of TGFβ in wound healing pathologies. Mechanisms of Ageing and Development journal. 2017; 172: 51–58.

Stephan Schreml, Rolf-Markus Szeimies, Lukas Prantl, MichaelLandthaler, Philipp Babilas. Wound healing in the 21st century. J Am Acad Dermatol. 2010; 63: 866–81.

Pauline Beldon. Basic science of wound healing. Surgery. 2010; 28: 409–12.

Shailendra Singh, Alistair Young, Clare-Ellen McNaught. The physiology of wound healing. Basic Science. 2017; 35: 473–77.

Tanya J. Shaw, Paul Martin. Wound repair at a glance. Journal of Cell Science. 2009; 122: 3209–13.

Sabine A.Eming, Thomas Krieg, Jeffrey M.Davidson. Inflammation in wound repair: Molecular and cellular mechanisms. Journal of Investigative Dermatology. 2007; 127: 514–25.

Geoffrey C. Gurtner, Sabine Werner, Yann Barrandon, Michael T. Longaker. The Wound repair and regeneration. Nature. 2008; 453: 314–21.

Ana Cristina de Oliveira Gonzalez, Tila Fortuna Costa, Zilton de Araújo Andrade, Alena Ribeiro Alves Peixoto Medrado. Wound healing - A literature review. An Bras Dermatol. 2016; 91: 614–20.

T Velnar, T Bailey, V Smrkolj. The Wound Healing Process : an Overview of the Cellular and Molecular Mechanisms. The Journal of International Medical Research. 2009; 37: 1528–42.

Dylan R. Childs, Ananth S. Murthy. Overview of Wound Healing and Management. Surgical Clinics of North America. 2017; 97: 189–207.

Hani Sinno and Satya Prakash. Complements and the Wound Healing Cascade : An Updated Review. Plastic Surgery International. 2013; 2013: 1–7.

Jie Li, Juan Chen, Robert Kirsner. Pathophysiology of acute wound healing. Dermatology & Cutaneous Surgery. 2007; 25: 9–18.

Marshall P. Welch, George E Odland, Richard A. E Clark. Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. The Journal of Cell Biology. 1990; 110: 133–45.

Heiko Sorg, Daniel J. Tilkorn, Stephan Hager, Jörg Hauser, Ursula Mirastschijski. Skin Wound Healing: An Update on the Current Knowledge and Concepts. Eur Surg Res. 2017; 58: 81–94.

Antonio CL Campos, Anne K Groth, Alessandra B Branco. Assessment and nutritional aspects of wound healing. Current Opinion in Clinical Nutrition & Metabolic Care. 2008; 11: 281–88.

Robyn Rayner. Effects of cigarette smoking on cutaneous wound healing. Primary Intention. 2006; 14: 100–102,104.

Robert D. Galiano, Oren M. Tepper, Catherine R. Pelo, Kirit A. Bhatt, Matthew Callaghan, Nicholas Bastidas, Stuart Bunting, Hope G. Steinmetz, Geoffrey C. Gurtner. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. The American Journal of Pathology. 2004; 164: 1935–47.

Downloads

Published

2018-09-30

Issue

Section

Review Article