FORMULATION, DEVELOPMENT AND EVALUATION OF TOPICAL LIPOSOMAL GEL OF FLUCONAZOLE FOR THE TREATMENT OF FUNGAL INFECTION

Nikita Agrawal, Dr. Vimukta Sharma, Dr. Rahul Maheshwari

Abstract


The present work on the preparation of topical liposomal gel containing fluconazole is an attempt to utilize the immense potential of liposomes as a carrier to increase the permeability. Liposomal encapsulation showed more drug retention compared with plain drug gel .

Further, the physicochemical modification in the drug by means of phospholipid membrane also promises to prolong the drug action. A number of problem associated with drug molecule such as bioavailability, degradation, stability and side effects can be overcome by incorporating it into liposomes. The liposomes of fluconazole was prepared by film hydration   method and evaluated.  The In vitro release of the formulation was studied and found to be more efficient than plain gel.  Creation of reservoir effect for drug   in skin due to deposition of other components of liposomes with drug into the skin and thereby increasing the drug retention capacity into the skin. Liposomal formulations were more spherical with stable zeta potential and mono-disperse with no clumping.

Variables such as amount of phospholipid, amount of stabilizer have a profound effect on the vesicle size and entrapment efficiency. Liposomal dispersion and gels were found to increase the skin permeation and deposition compared to control. Drug release of all batches was studied. Stability studies performed for Liposomal gel indicates the prepared liposomes have more stability at freezing temperature than that of room temperature.

Fluconazole molecules could be successfully entrapped in liposomes with reasonable drug loading. Hence from results obtained it can be concluded that liposomal gel containing fluconazole has potential application in topical delivery for the treatment of fungal skin ailments.


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