COMPARATIVE HPTLC FINGERPRINTING ANALYSIS OF DIFFERENT PHARMACEUTICAL DOSAGE FORMS OF PUNARNAVADI KWATHA

Abstract

Kwatha (decoction) Kalpana (preparation) is most widely used dosage form in Ayurveda pharmaceutics especially in Kerala. Punarnavadi kwatha is one among the commonly used medicine in Ayurvedic practice, mentioned in Chakradatta in sopha chikitsa. In the modern lifestyle it is considered that Kwatha (decoction) Kalpana (preparation) has certain disadvantages in terms of shelf life, palatability etc. In order to overcome these disadvantages, different modified dosage forms are made available by the pharmaceutical companies. These includes concentrated Kwatha, Kwatha tablets, Kwatha sookshma choornam etc. Different pharmaceutical dosage forms of Kwatha are available in the market and they are extensively prescribed by the physicians. But Ayurveda practitioners are always doubtful about the efficacy of these dosage forms. So, the present study HPTLC fingerprinting analysis of different pharmaceutical dosage forms of Punarnavadi kwatha. aimed to assess the difference in phytoconstituents. Different pharmaceutical dosage forms include P1-classically prepared Kwatha (decoction), P2- Concentrated Kwatha (decoction), P3- Kwatha (decoction) tablet and P4- Sookshma choorna Kwatha (decoction). In the present study P1 is prepared according to traditional method and P2, P3 and P4 were purchased from GMP certified companies. The method of selection of the company was based on the lottery method. In HPTLC finger printing, maximum percentage area of phytoconstituents was in P1- classically prepared kwatha. The study revealed that maximum number of phytoconstituents were present in the Kwatha (decoction) prepared according to classical method.  

Keywords- HPTLC fingerprinting, pharmaceutical dosage forms of Punarnavadi kwatha.