PHYTOCHEMICAL AND PHARMACOLOGICAL INSIGHTS INTO CLERODENDRUM INFORTUNATUM LINN. IMPLICATIONS IN WOUND HEALING AND THERAPEUTIC APPLICATIONS

Abstract

Background: Clerodendrum infortunatum, commonly known as Bhaandira, is a well-known medicinal plant in traditional systems of medicine. It has been extensively described in Ayurveda for its therapeutic potential in managing inflammatory conditions, skin disorders, and wound healing. Modern phytochemical and pharmacological studies have further validated its bioactive profile and diverse biological activities. AIM To evaluate the phytochemical and pharmacological properties of Clerodendrum infortunatum with special reference to its wound healing potential.  OBJECTIVES To identify and summarize the major phytochemical constituents present in Clerodendrum infortunatum. To analyze its pharmacological activities related to wound healing such as anti-inflammatory, antimicrobial, and antioxidant effects.  To understand its role in wound management from an Ayurvedic perspective including Vrana Shodhana and Vrana Ropana. To explore its broader therapeutic applications in modern and traditional medicine. Methods: A comprehensive review of classical Ayurvedic texts and contemporary scientific literature was conducted. Databases including PubMed, Scopus, and Google Scholar were explored to collect relevant information on phytochemistry, pharmacological actions, and experimental studies related to wound healing.

Results:
Clerodendrum infortunatum contains a wide range of phytoconstituents such as flavonoids, alkaloids, glycosides, steroids, and phenolic compounds. These constituents exhibit significant pharmacological activities including anti-inflammatory, antimicrobial, antioxidant, analgesic, and wound healing effects. Experimental studies have demonstrated enhanced wound contraction, increased collagen synthesis, and improved epithelialization. From an Ayurvedic perspective, its properties such as Katu Tikta Rasa, Laghu Ruksha Guna, and Ushna Virya contribute to Vrana Shodhana and Vrana Ropana actions, supporting its role in effective wound management. Conclusion: The integration of phytochemical richness and pharmacological efficacy establishes Clerodendrum infortunatum as a promising natural agent for wound healing and therapeutic applications. Further clinical studies are required to validate its efficacy and safety for standardized use in modern healthcare.