A CLINICAL STUDY TO EVALUATE THE EFFECT OF MADHUMEHARI CHURNA ON GLYCATED HEMOGLOBIN (HBA1C) IN PATIENT OF TYPE 2 DIABETES MELLITUS

Abstract

Madhumeha, one of the 20 types of Prameha described in Ayurveda, is analogous to Type 2 Diabetes Mellitus (T2DM) in modern medicine. It results from Agnimandya (impaired digestion), Medo Dhatu Dushti (lipid metabolism disorder), and Ojas Kshaya (loss of vitality), presenting with polyuria, polydipsia, and fatigue. Conventional therapies for T2DM emphasize glycemic control but may have long-term side effects. Ayurveda offers holistic management through herbal formulations such as Madhumehari Churna.A 36-year-old female patient with uncontrolled T2DM presented with polyuria, polydipsia, fatigue, and elevated HbA1c (8.3%). She was administered Madhumehari Churna (5 g, twice daily before meals with lukewarm water) for 12 weeks without any concomitant allopathic antidiabetic medication. Subjective symptoms and objective parameters, particularly HbA1c levels, were assessed before and after intervention. Marked clinical improvement was observed in polyuria, polydipsia, and fatigue. HbA1c reduced significantly from 8.3% at baseline to 5.8% after 3 months and further to 5.7% at 6 months, indicating effective long-term glycemic control. The therapy showed no adverse effects during the study period.The observed outcomes may be attributed to the synergistic effects of Madhumehari Churna’s herbal constituents such as Gudmar (Gymnema sylvestre) and Jamun (Syzygium cumini), which enhance insulin secretion,  inhibit intestinal glucose absorption, and improve insulin sensitivity. Madhumehari Churna demonstrated significant improvement in glycemic control and symptomatic relief in T2DM without adverse effects, suggesting its potential as a safe, effective adjunct therapy. Larger clinical studies are warranted to validate these findings.