SARCOPENIA EVALUATION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Authors

  • Aydın Teoman 1Bezmi Alem Vakif University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Istanbul

Abstract

Aim: The aim of our study was to investigate changes in muscle mass with especially the comparison between people DM patients.

Method: This randomized, prospective, controlled, single blind study was conducted in Physical medicine and Rehabilitation department of Bezm-i Alem Vakıf University, faculty of Medicine. The patient group individuals taken from patients with type 2 diabetes mellitus. Healthy individuals were enrolled as the control group patients. A total of 126 patients completed the study (63 study group, 63 control group). The patients were between the ages of 40 and 65 included in this study. Body composition of the subjects was measured by Bioelectrical impedance analysis method.

Muscle mass distribution of subjects with skeletal muscle index (SMI %):  Diabetic and nondiabetic patients evaluated with using total skeletal muscle mass (kg)/weight (kg) x100) formula.

Results: A total of 126 patients completed the study (63 study group, 63 control group). The clinical and demographic characteristics of the patients and the healthy controls are listed in Table 1. The mean age was 59.31 ± 8.17 years. The mean disease duration was 11.42±2.82 years. The most important finding of our study in patients with type 2 diabetic SMI values were significantly lower than the control group. In addition, BMI, fat mass and fat percentage was significantly higher in type 2 diabetic patients.

Conclusion: In conclusion, type 2 diabetes is associated with the excessive loss of skeletal muscle mass in older adults. Older adults with undiagnosed diabetes are at particularly high risk for the loss of skeletal muscle mass.

Keywords: Sarcopenia, Type 2 Diabetes Mellitus, body muscle mass

References

López-Candales A. Metabolic syndrome X: a comprehensive review of the pathophysiology and recommended therapy. J Med. 2001;32:283–300.

I. Janssen and R. Ross, “Linking age-related changes in skeletal muscle mass and composition with metabolism and disease,” Journal of Nutrition, Health andAging, vol. 9, no. 6, pp. 408–419,2005.

A. J. Cruz-Jentoft, J. P. Baeyens, J. M. Bauer et al., “Sarcopenia: European consensus on definition and diagnosis,” Age and Ageing, vol. 39, no. 4, pp. 412–423, 2010.

Kalyani RR, Metter EJ, Ramachandran R, Chia CW, Saudek CD, et al. (2012) Glucose and insulin measurements from the oral glucose tolerance test and relationship to muscle mass. J Gerontol A Biol Sci Med Sci 67: 74–81.

Kim YS, Lee Y, Chung YS, Lee DJ, Joo NS, et al. (2012) Prevalence of sarcopenia and sarcopenic obesity in the Korean population based on the Fourth Korean National Health and Nutritional Examination Surveys. J Gerontol A Biol Sci Med Sci 67: 1107–1113.

Kim KS, Kim SK, Sung KM, Cho YW, Park SW (2012) Management of type 2 diabetes mellitus in older adults. Diabetes Metab J 36: 336–344.

Chin SO, Rhee SY, Chon S, Hwang YC, Jeong IK, et al. (2013) Sarcopenia is independently associated with cardiovascular disease in older Korean adults: the Korea National Health and Nutrition Examination Survey (KNHANES) from 2009. PLoS One 8: e60119.

Lukaski HC, Johnson PE, Bolonchuk WW, et al. Assessment of fat-free mass using bioelectrical impedance measurements of the human body. Am J Clin Nutr 1985;41:810–17.

Kim TN, Yang SJ, Yoo HJ, Lim KI, Kang HJ, Song W, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM. Prevalence of sarcopenia and sarcopenic obesity in Korean adults: the Korean sarcopenic obesity study. Int J Obes (Lond) 2009;33:885–892.

Gougeon R, Morais JA, Chevalier S, Pereira S, Lamarche M, Marliss EB.: Determinants of whole-body protein metabolism in subjects with and without type 2 diabetes. Diabetes Care 2008; 31: 128– 133.

Womack L, Peters D, Barrett EJ, Kaul S, Price W, Lindner JR. Abnormal skeletal muscle capillary recruitment during exercise in patients with type 2 diabetes mellitus and microvascular complications. J Am Coll Cardiol. 2009;53:2175–2183.

Park SW, Goodpaster BH, Strotmeyer ES, de Rekeneire N, Harris TB, Schwartz AV, Tylavsky FA, Newman AB. Decreased muscle strength and quality in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes 2006;55:1813–1818.

Rasmussen BB, Fujita S, Wolfe RR, et al. Insulin resistance of muscle protein metabolism in aging. Faseb J. 2006; 20:768–769.

Schwartz MW. Neuronal pathways regulating food intake and body adiposity. Ann Endocrinol (Paris). 2002; 63:117–120.

Lanza IR, Short DK, Short KR, Raghavakaimal S, Basu R, Joyner MJ, McConnell JP, Nair KS.: Endurance exercise as a countermeasure for aging. Diabetes 2008; 57: 2933– 2942.

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Published

2016-05-30

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Original Research Article