Soumya B, Dr. Govind Nayakv, Dr. Abhilasha Singh, Dr. Mehta Parulben D.


Erythromycin is an antibiotic used for the treatment of a number of bacterial infections. This includes respiratory tract infections, skin infections, Chlamydia infections, pelvic inflammatory disease, and syphilis. Topical erythromycin is used for the treatment of inflammatory acne vulgaris that occurs due to activity against propioni bacterium acne. It is slightly soluble in water and freely soluble in methanol. Erythromycin base are examples of topical drugs with poor dermal localization due to lipophilicity. Elastic liposomes could be suitable carriers for these drugs with a potential impact on their dissolution. Total Six formulations were prepared using varying amount of Soya-phosphatidylcholine, Span 80 and drug and evaluated for Vesicle size and Entrapment efficiency. Formulation F4 which contain smallest vesicle size and increase in entrapment efficiency, Formulation F4 Sleeted as optimized formulation for further evaluation.

The optimized batch of elastic liposomes was further incorporated into gel base and evaluated for pH, Spreadability, Measurement of viscosity, Drug content and In-vitro diffusion study. The value of vesicle size, and entrapment efficiency. The vesicle size of all elastic liposomes varied between 145.45±0.24 and 225.45±0.21nm where as entrapment efficiency was found between 65.85±0.45 to 73.32±0.12%.  Erythromycin loaded elastic liposomes were successfully prepared with an excellent loading efficiency of about 73.32±0.12%. The Erythromycin loaded elastic liposomes exhibited adequate size, stability and flexibility characteristics. Furthermore, elastic liposomes extended the Erythromycin release time, achieving sustained release for almost 10 h.

Key Words: Elastic liposomes, Formulation, Evaluation, Erythromycin

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