Arun Kumar, Mr. Amit Dubey, Dr. Satkar Prasad, Dr. Sailesh Kumar Ghatuary


Ulcer has long been recognized as one of the most important gastrointestinal problem. With the ever growing interest in natural medicine, many plants have been screened and reported to be useful in treating and managing ulcer. Phyllanthus urinaria has several pharmacological properties including anti-inflammatory and anti-diarrhoeal. In spite of its uses in the traditional medicine against various ailments, this plant has so far not been screened for anti-ulcer activity. We report on the anti-ulcer activity of hydroalcoholic extract of Phyllanthus urinaria. The results of the present study have shown that hydroalcoholic extract of Phyllanthus urinaria possess gastro protective activity, as evidenced by its significant inhibition in the formation of ulcers induced by ethanol.  As flavonoids have been identified in the methanolic extract, we believe that the anti-ulcer activity of this extract is probably due to the antioxidant activity of the extract.  Antioxidant activities of flavonoids have been well documented in the literature. Moreover, flavonoids have been reported for their anti-ulcerogenic activity and gastric protection already.  Sub-acute toxicological studies have revealed that the methanolic extract of hydroalcoholic extract of Phyllanthus urinaria show slight CNS depression for a few hours after treatment at the dose of 2000 mg /kg. However, there was no sign of toxicity or mortality up to 14 days indicates that the extract is relatively safe. Any substance that is not toxic at 2000 mg /kg is considered relatively safe. 

Key words: Phyllanthus urinaria, hydroalcoholic extract, Anti Ulcer activity, Ethanol induced

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