Saumya Dubey, Prashant Maithel, Dr. Satkar Prasad, Dr. Sailesh Kumar Ghatuary


Lagerstroemia parviflora Roxb leaf extracts showed the presence of phytochemical constituents such as terpenoids, steroids, phytosterols, flavonoids, carbohydrates, proteins and saponin. There are no previous preliminary phytochemical and other reports in this plant. Also, previous studies on the immunomodulatory activity of Lagerstroemia parviflora were done in different geographical regions of the world and this has been reported to affect the nutritional and the phytochemical composition of the plant and hence its medicinal value effectiveness may differ geographically. The study therefore, determined the immunomodulatory activity of methanolic leaf extracts of the Lagerstroemia parviflora in nonimmunosuppressed Wistar albino rats.

Total phenols and flavonoids contents, as well as scavenging activity of DPPH in Hydroalcoholic extract obtained from Lagerstroemia parviflora leaves, was evaluated. The total phenol and flavonoids content of the Hydroalcoholic extract Lagerstroemia parviflora leaves shows the excellent amount. Hydroalcoholic extract Lagerstroemia parviflora leaves showed the high radical scavenging activity of DPPH. The in-vivo Immunomodulatory activity was performed on Hydroalcoholic extract Lagerstroemia parviflora (leaves).Various parameters have been evaluated such as Neutrophils adhesion test, Carbon clearance test, Indirect heamagglutination test, Mice lethality test.  The study was carried out using four different methods, each of which provides information about effect on different components of the immune system. The variety of plant products can modulate immune reaction either by stimulation or suppression and may assist as a supportive therapy along with conventional drugs in immune compromised patients.

Key words: Immunomodulatory Activity, Lagerstroemia parviflora, Hydroalcoholic Extract

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