ETHNO-MEDICINAL, PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATION ON RAʿI IBL (HELICTERES ISORA LINN.) -A PERSUASIVE UNANI MEDICINAL PLANT

Anwar Jamal, Aisha Siddiqui, Azma Waseem, Mohammad Fazil, Asim Ali Khan

Abstract


Herbal Medicines are being used since time immemorial in organized and unorganized form such as tribal, native & folk forms. Raʿi Ibl (Helicteres isora) is a medical plant used in Unani System of Medicine, which grows in Central and Western India, Peninsula and Ceylon as far as west Jammu, eastward to Nepal, Bihar and Bengal. It is commonly known as Altwaallatu/ Kisht ba’r Kisht/ Deer’s Horn. It is also known as Marorphali due to screw like appearance of its fruit. Fruit are useful in intestinal disturbances such as colic, griping of bowels, flatulence and diarrhea in children.

H. isora is a rich source of antioxidants, carbohydrates, protein, fiber, calcium, phosphorus and iron. Active phyto-constituents include gallic acid, caffeic acid, vanillin and p-coumaric acid. It has Mulattif (Demulscent), Qabiz (Astringent), Muhallil (Resolvent), Mushil-i Balgham (Phlegmagogue), Mufatteh-i Sudad (Deobstruent), Jali (Detergent) and Daf-i Sumoom (Antidote)  properties and used in Ziabetus (Diabetes), Zaheer (Dysentery), Falij (Paralysis) Waja-ul Meda (Gastralgia), Deedaan-i Ama’a (Helminthiasis) and Suql-i Meda (Heaviness and fullness of stomach) in Unani Medicine. The medicinal plant has been evaluated for antioxidant, antibacterial and anti-plasmid, anti-diarrheal, anticancer, antinociceptive, hypolipidaemic, hepatoprotective and wormicidal activities etc.

Keywords:

Raʿi Ibl, Marorphali, Helicteres isora L., Unani Medicine, Anti-diarrheal


Full Text:

PDF

References


Anonymous. The Wealth of India, Raw Materials: National Institute of Science Communication (CSIR), Vol.V (H-K). Dr. K.S.Krishnan Marg, New Delhi; 1997. p. 27-29.

Kirtikar KR and Basu BD. Indian Medicinal Plants: International Book Distributors, Vol.I. Rajpur Road, Dehradun, India; 1995. p.370-372.

Dymock W. Pharmacographia Indica: Education Society’s Press, Vol I. Byculla, Bombay; 1890. p. 231-232.

Anonymous, Standardization of single drugs of Unani Medicine: Central Council for Research in Unani Medicine, Part-IV. Dept. of AYUSH, M/o Health & Family Welfare, Govt. of India, N. Delhi; 2006. p.150-158.

Chopra RN, Nayar CL, Chopra IC. Glossary of Indian Medicinal Plants, Council of Scientific & Industrial Research, New Delhi, 1956, PP. 131.

Bean MF, Antoun M, Abramson D, Chang CJ, MCLaughlin JL, Cassady JM. Cucurbitacin B and iso-cucurbitacin B: Cytotoxin components of Helicteres isora. Journal of Natural Products 1985; 48 (3): 500.

Kumar N and Singh AK. Plant Profile: Phytochemistry and Pharmacology of Avartani (Helicteres isora Linn.); A review. Asian Pacific Journal of Tropical Biomedicine 2014; 4 (suppl 1);S22-S-26.

Nadkarni KM. Indian Materia Medica:, Vol.1. Bombay Popular Prakashan; 1976. P.615-616.

Mohd Sharif Khan. Taleef-e Sharifi (Persian): Akmal al Matabae, New Delhi: 1847. p. 105.

Ibn Sina. Al Qanun fit Tibb (Arabic): Vol.II. Institute of History of Medicine and Medical Research, New Delhi: 1987. p.193, 340.

Azam Khan. Muheet-e Azam: Vol.4 (Urdu Tajuma). Central Council for Research in Unani Medicine, Ministry of AYUSH, Government of India, New Delhi:2018. p.593.

Ibn-e Baitaar. Al Jamiul Mufradat Al Advia wal Aghzia: Vol.IV (Urdu Tarjuma).Central Council for Research in Unani Medicine, M/o Health & Family Welfare, Government of India, New Delhi: 2003. p.176.

Kabiruddin. Makhzanul Mufradat: Sheikh Mohd. Basheer and Sons, Urdu Bazaar, Lahore: Year (NM).p.541-542.

Munshi Gulam Nabi. Makhzanul Mufrada’t wa Murakkaba’t (Khawasul Advia):Central Council for Research in Unani Medicine, M/o Health & Family Welfare, Govt. of India, New Delhi; 2007. p.224.

Najmul Ghani, Khazainul Advia:Vol.6. Central Council for Research in Unani Medicine, M/o Health & Family Welfare, Govt. of India, New Delhi;2010. p.274-75.

Asolkar LV, Kakkar KK, Chakre OJ. Glossary of Indian Medicinal Plants with active Principles. Part-I (A-K). Publication & Information Directorate(CSIR), New Delhi: 1992. P.348.

Chopra RN, Chopra IC, Verma, BS. Supplement to Glossary of Indian Medicinal Plants. Publication & Information Directorate, Hillside Road, New Delhi: year (NM).P. 36.

Gayathri P, Gayathri Devi S, Sivagami Srinivasan SS. Screening and quantization of phytochemicals and nutritional components of the fruit and bark of Helicteres isora. Hygeia Journal for drug and medicines 2010; 2 (1):57-62.

Jain A, Sinha P, Desai NS. Estimation of flavonoid, phenol content and antioxidant potential of Indian Screw tree (Helicteres isora L.). International Journal of Pharmaceutical Sciences and Research 2014; 4: 1320-1330.

Raaman N, Bala SK. Antioxidant and anticancer activity of Helicteres isora dried fruit solvent extract. Journal of Academic and Industrial Research 2012; (1): 148-152.

Satake T, Kamiya K, Saiki Y, Hama T, Fujmoto Y, Kitanaka S, Umar M. Studies on the constituents of fruits of Helicteres isora L. Chemical and Pharmaceutical Bulletin-Tokyo 1999; 47: 1444-1447.

Scozoni L, Benaducci T, Almeida AMF, Silva DHS, Bolzani VDS, Gianimni MJSM. The use of standard methodology for determination of antifungal activity of natural products against medical yeasts candida sp. and cryptococcus sp. Brazilian J Microbiology 2007; 38:391-397.

Rios JL, Recio MC, Villar A. Screening methods for natural products with antimicrobial activity: a review of the literature. J Ethnopharmacol 1988; 23(2-3):127-149.

Venkatesh S, Sailaxmi K, Madhava B, Ramesh M. Antimicrobial Activity of Helicteres isora root. Indian Journal of Pharmaceutical Sciences 2007; (Sep.-Oct.): 687-689.

Kumar TM, Christy AM, Ramya RC, Malaisamy M, Sivaraj C, Arjun P. Antioxidant and anticancer activity of Helicteres isora dried fruit solvent extracts. J Acad Indus Res 2012; 1(3): 148-152.

Kumar G, Murugesan AG. Hypolipidaemic activity of Helicteres isora L. bark extracts in streptozotocin induced diabetic rats. J Ethnopharmacol 2008; 116(1): 161-166.

Boopathy RA, Elanchezhiyan C, Sethupathy S. Antihyperlipidemic activity of Helicteres isora fruit extract on streptozotocin induced diabetic male wistar rats. Eur Rev Med Pharmacol Sci 2010; 14: 191-196.

Shriram V, Jahagirdar S, Latha C, Kumar V, Dhakephalkar P, Rojatkar S. Antibacterial & antiplasmid activities of Helicteres isora L. Indian J Med Res 2010; 132: 94-99.

Kumar G, Banu GS, Murugesan AG. Effect of Helicteres isora bark extracts on heart antioxidant status and lipid peroxidation in streptozotocin diabetic rats. J Appl Biomed 2008; 6: 89-95.

Kumar G, Banu GS, Murugesan AG, Pandian MR. Effect of Helicteres isora bark extracts on brain antioxidant status and lipid peroxidation in streptozotocin diabetic rats. Pharm Biol 2007; 45(10): 753-759.

Varghese E, Narayanan SS, Gopal RV, Nair A, Chittethu AB, Anson TA. Anticancer activity of chloroform extract of Helicteres isora Linn. Int J Pharm Technol 2011; 3(2): 2560-2564.

Venkatesh S, Laxmi KS, Reddy BM, Ramesh M. Antinociceptive activity of Helicteres isora Linn. Fitoterapia 2007; 78(2): 146-148.

Chitra MS, Prema S. Hepatoprotective activity of Helicteres isora Linn. against CCl4 induced hepatic damage in rats. Hamdard Medicus 2009; 52(1): 112-115.

Chopra RN, Nayar SL, Chopra IC. Glossary of Indian medicinal Plants: Reprint. New Delhi, Publication and Information Directorate, CSIR; 2012. p. 63-69.

Asolkar LV, Kakkar KK, Chakre OJ. Second supplement to glossary of Indian medicinal plants with active principles. Reprint. New Delhi, Publication and Information Directorate, CSIR; 2012. p.78- 83.

Anonymous, Standardization of single drugs of Unani Medicine. Central Council for Research in Unani Medicine, Part-V. Dept. of AYUSH, M/o Health & Family Welfare, Govt. of India, N. Delhi; 2006.p.178-184.

Anwar J, Aisha S, Azma W and Afshan K. “Kaiphal” (Myrica nagi Thunb.): A versatile Medicinal Plant with its phytochemistry, pharmacology and traditional Uses: A Compendious Review. European Journal of Biomedical and Pharmaceutical Sciences2020; 7 (9):p.186-191.

Anonymous, National Formulary of Unani Medicine, part-1, M/o Health & Family Welfare (Department of AYUSH), New Delhi; 2006.p.129.


Refbacks

  • There are currently no refbacks.