EVALUATION OF IN VIVO HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ROOTS OF RICINUS COMMUNIS (EE-R-RC) AGAINST CCL4 INDUCED RAT MODEL

Asish Bhaumik, P. Kalyani, Ch. Ram Naresh, K. Krishnamachary

Abstract


The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion. The liver is the only human internal organ capable of natural regeneration of lost tissue; as little as 25% of a liver can regenerate into a whole liver. This is, however, not true regeneration but rather compensatory growth in mammals. The lobes that are removed do not regrow and the growth of the liver is a restoration of function, not original form. This contrasts with true regeneration where both original function and form are restored. The main aim and objective of the present research work was the preliminary phytochemical screening of primary and some secondary metabolites present in ethanolic extract of roots of Ricinus communis. The in vivo hepatoprotective activity was performed in Ccl4 induced rat model and histopathological analysis was done by FNAB. The in vivo experimental data displayed that the elevated levels of SGOT, SGPT, ALP and Sr. bilirubin were mainly due to CCl4 intoxication,  reduced significantly (*P<0.05) in rats, after treatment with EE-R-RC. Treatment with EE-R-RC at a dose of 100 mg/kg b. w. decreased  the SGOT: 11.69%,  SGPT: 22.50%, ALP: 3.64%, and Serum bilirubin levels by  32.74%, (significantly) respectively, while at higher dose of 200 mg/kg b. wt. was more effective, causing a reduction of SGOT: 24.30%, SGPT: 41.09%, SALP: 11.97% and Sr. bilirubin: 47.16%, Silymarin is used as standard drug showed a significant reduction of level of SGOT: 53.35%, SGPT: 48.43%, SALP: 47.43% and Sr. bilirubin: 75.35% respectively receiving CCl4 alone.

Key words:  Metabolites; hepatoprotective; FNAB; SALP etc.


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How to cite this article:

K. Krishnamachary, M. Prasad, Ch. Ram Naresh; Evaluation of in vivo hepatoprotective activity of ethanolic extract of roots of Ricinus Communis (EE-R-RC) against CCL4 induced rat model; Panacea Journal of Pharmacy and Pharmaceutical Sciences 2018:7(3);83-98.


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