Andugula Kavitha, A. Narendra Babu, Rama Rao. Nadendla, Chandra Sekhar G


The aim of the present study is to examine acute toxicity studies for extracts of whole plant of cissus quadrangularis in the form of aqueous slurry as per the organization for economical and cooperation development (OECD) guidelines in Swiss albino mice weighing 23-30 g. The dose of 50, 100, 200, 500, 1000, 1500, 2000 and 3000 mg per kg body weight of aqueous extract was administered orally. All the groups animals were almost continuously observed for mortality and behavioral changes during first 24 h and then daily for 14 d. On 15th day the observations of behavioral changes and changes in body weight, food and water intake as well as cage side observations were reported. There was no abnormality observed in all groups. The whole plant aqueous extract have no any significant toxic effect in Swiss albino mice and the plant material was found to be non-toxic.

Keywords:  cissus quadrangularis, acute toxicity, whole plant powder, aqueous extract.

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Skoog Da, West DM, Holler FJ. Fundamntal of Analytical Chemistry, Saunders college Publishing, USA, 7th edition, 1996, 1-15.

Ambast SP, The useful plants of India, Publication and information division, CSIR, New Delhi, India, 1986.

Asolkar LV, Kakkar KK, Chakra OJ. Second Supplement to glossary of Indian me-dicinal plants with active principles. Part I (A-K). Publication and Information Division, CSIR, New Delhi,India, 1992.

Petroleum ether extract of Cissus quadrangularis (LINN) stimulates the growth of fetal bone during intra uterine developmental period: a morphometric analysisBhagath Kumar PotuI; Muddanna S RaoI; Gopalan Kutty NII; Kumar MR BhatI; Mallikarjuna Rao ChamallamudiII; Soubhagya Ranjan NayakIII

Identification of chemical compounds in Cissus quadrangularis L. Variant-I of different sample using GC-MS analysis T. Sathish Kumar1 , A. Anandan1 and M. Jegadeesan2. Archives of Applied Science Research, 2012, 4 (4):1782-1787.

Determination of marker constituents from Cissus quadrangularis Linn and their quantitation by HPTLC and HPLC. Mehta M, Kaur N, Bhutani K., Phytochem Anal, 2001, 12, 91-105.

Pharmacological and Therapeutic Activity of Cissus quadrangularis: An Overview Garima Mishra1*, Saurabh Srivastava2 , B.P.Nagori3, International Journal of PharmTech Research, Vol.2, No.2, pp 1298-1310.

Indian Herbal Pharmacopoeia, pub: Regional Research Laboratory, Jammu Tawi & Indian Drug Manufacture’s Association Mumbai, 1999; (2): 85-92.

Pingale SS and avvaru Radha Krishna. Acute toxicity study for Achyranthes Aspera Leaves, Journal of Pharmacy Research, 2011; 4(1): 2221-2222

Pingale SS and Shewale SS. Acute Toxicity Study of Phyllanthus Amarus, Interna-tional Journal of Pharmaceutical Sciences Review and Research 2011 9(1): 81-84

Pingale SS and Virkar PS. Evaluation of Acute Toxicity for Abutilon Indicum. Scholars Research Library, Der Pharmacia Lecture, 2011; 3(3): 37-42.

Pingale SS and Pokharkar RD. Acute Toxicity study for Cissus quadrangularis whole plant powder, Pharmacologyonline Newsletter, 2008; 2:256-262.

Acute and sub-acute toxicity studies on the effect of Senna alata in Swiss Albino mice, Toxicology/ Research ArticleS.Roy1, B. Ukil1 and L.M. Lyndem1*.

Pingale SS, Pingale MS and Pokharkar RD. Stability study of a herbal drug, Pharmacologyonline Newsletter, 2008; 1: 20-13.

Acute toxicity study for Tinospora cardifolia, Shirish Sadashiv Pingale*, IJRAP 2011 2(5): 1571-1573.

How to cite this article:

Andugula. Kavitha*, A. Narendra Babu, Rama Rao. Nadendla, Chandra Sekhar. G, Acute toxicity study of Cissus Quadrangularis in swiss albino mice; Panacea Journal of Pharmacy and Pharmaceutical Sciences 2018:7(1);748-756.


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