ACUTE TOXICITY STUDY OF CISSUS QUADRANGULARIS IN SWISS ALBINO MICE

Andugula Kavitha, A. Narendra Babu, Rama Rao. Nadendla, Chandra Sekhar G

Abstract


The aim of the present study is to examine acute toxicity studies for extracts of whole plant of cissus quadrangularis in the form of aqueous slurry as per the organization for economical and cooperation development (OECD) guidelines in Swiss albino mice weighing 23-30 g. The dose of 50, 100, 200, 500, 1000, 1500, 2000 and 3000 mg per kg body weight of aqueous extract was administered orally. All the groups animals were almost continuously observed for mortality and behavioral changes during first 24 h and then daily for 14 d. On 15th day the observations of behavioral changes and changes in body weight, food and water intake as well as cage side observations were reported. There was no abnormality observed in all groups. The whole plant aqueous extract have no any significant toxic effect in Swiss albino mice and the plant material was found to be non-toxic.

Keywords:  cissus quadrangularis, acute toxicity, whole plant powder, aqueous extract.


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How to cite this article:

Andugula. Kavitha*, A. Narendra Babu, Rama Rao. Nadendla, Chandra Sekhar. G, Acute toxicity study of Cissus Quadrangularis in swiss albino mice; Panacea Journal of Pharmacy and Pharmaceutical Sciences 2018:7(1);748-756.


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