P K Nimase, N R More


Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing hydroxypropylmethylcellulose (K100M) and sunflower oil using the technique of three variables at three levels (3 power 3) factorial design and twenty-seven possible batches were prepared. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations showed floating lag time below 2 minutes and showed total floating duration more than 10 hours. The result of in-vitro dissolution studies revealed that the formulation F14 was showing sustained release pattern of clarithromycin. The release rate, entrapment efficiency, drug loading and buoyancy was greater with formulation containing 2 percent sodium alginate solution and 5 percent calcium chloride solution along with 5 ml sunflower oil. 

Keywords: Floating alginate beads; emulsion gelation; clarithromycin; controlled release.

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S. Arora, J. Ali, A. Ahuja, R. K. Khar and S. Baboota. Floating Drug Delivery Systems: A Review AAPS Pharm. Sci. Tech. 2005; 6 (3): 47.

P. Sriamornsak , N. Thirawong and S. Puttipipatkhachorn. Morphology and buoyancy of oil-entrapped calcium pectinate gel beads. The AAPS Journal. 2004; 6: 24.

A. Streubel, J. Siepmann and R. Bodmeier. Floating microparticles based on low density foam powder. Int. J. Pharm. 2002; 241:279-292.

N. Rouge, P. Buri and E. Doelker. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int. J. Pharm. 1996; 136(1-2): 117-139.

Y. L. Patel, P. Sher and A. P. Pawar. The Effect of Drug Concentration and Curing Time on Processing and Properties of Calcium Alginate Beads Containing Metronidazole by Response Surface Methodology. AAPS Pharm. Sci. Tech. 2006; 86.

H. G. Brittain. In Analytical Profiles of Drug Substances and Excipients. . Vol. 24, Academic Press, California,

M. Nama, C. Gonugunta and P. Reddy Veerareddy. Formulation and Evaluation of Gastroretentive Dosage Forms of Clarithromycin. AAPS Pharm. Sci. Tech. 2008; 9(1): 231-237.

Y. D. Tang, S. S. Venkatraman, F. Y. C. Boey and L. W. Wang. Sustained release of hydrophobic and hydrophilic drugs from a floating dosage form. Int. J. Pharm. 2007; 336:159-165.

P. K. Choudhury and M. Kar. Preparation of alginate gel beads containing metformin hydrochloride using emulsion- gelation method. Tropical J. Pharm. Res. 2005; 4 (2): 489-493.

A. K. Seth and A. N. Mishra. Preparation and optimization of idoxuridine Liposomes. Ind. J. Pharm. Sci. 2005; 67(1): 89-95.

S. S. Badve, P. Sher, A. Korde and A. P. Pawar. Development of hollow/porous calcium pectinate beads for floating-pulsatile drug delivery. Euro. J. Pharm. 2007; 65:85-93.

S. Sharma and A. Pawar. Low density multiparticulate system for pulsatile release of meloxicam Int. J. Pharm. 2006; 313:150-158.

S. Gupta and N. Aggarwal. Stomach-Specific Drug Delivery of 5-Fluorouracil Using Floating Alginate Beads. The AAPS Journal. 2007; 8 (2): 48.


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