PREPARATION AND EVALUATION OF MULTIPLE-UNIT FLOATING DRUG DELIVERY SYSTEM OF CLARITHROMYCIN

P K Nimase, N R More

Abstract


Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing hydroxypropylmethylcellulose (K100M) and sunflower oil using the technique of three variables at three levels (3 power 3) factorial design and twenty-seven possible batches were prepared. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations showed floating lag time below 2 minutes and showed total floating duration more than 10 hours. The result of in-vitro dissolution studies revealed that the formulation F14 was showing sustained release pattern of clarithromycin. The release rate, entrapment efficiency, drug loading and buoyancy was greater with formulation containing 2 percent sodium alginate solution and 5 percent calcium chloride solution along with 5 ml sunflower oil. 

Keywords: Floating alginate beads; emulsion gelation; clarithromycin; controlled release.


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