FORMULATION, DEVELOPMENT AND EVALUATION OF LIPOSPHERE OF AN ANTI HIV DRUG ZIDOVUDINE
Abstract
HIV (interferes with body’s immune system. As a result of this body is more likely prone to other infections and cancer which further prove fatal. In a standard antiretroviral therapy commonly called as ART is combination of at least 3 antiretroviral (ARV) drugs which is intended for maximal suppression of HIV virus in the body. There are unpleasant side effects of anti-HIV drugs. Therefore, there is a pressing call for improved drugs and more effective drug targeting systems that would address various challenges, improve the efficacy, and be cost-effective liposome based therapy represent convenient approach to improve the delivery of anti -HIV agents into the infected cells improving efficacy of drugs and reducing adverse effect. Thus aim of this study is formulation development & evaluation of liposphere of Zidovudine. Results showed that the maximum percentage yield and entrapment efficiency was found formulation F3 (78.85±0.14). The mean particle size of optimized formulation F3 lipospheres was 236.2 nm. The zeta potential of F3 lipospheres was found -29.4 Mv. The r2 values for first order was found to be 0.994 suggesting release kinetics follow First order release kinetics. So, it can be concluded that Zidovudine Lipospheres may be a promising drug delivery system for HIV-1 treatment.
Keywords: HIV, Liposphere, Zidovudine, Antiretroviral Therapy (ART),
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