A ROLE OF GUT MICROBIOME IN DIABETIC PATIENTS WITH INFLAMMATORY BOWEL DISEASE AS WELL AS COVID-19 INFECTION

Authors

  • Dr. S. Selva Kumar
  • Dr. J. Pradeep

Abstract

Microbial population had intense to have an infection on humans particularly commensals. Now there was a wide range of knowledge on diabetic as well as progression and immune function about the immunological studies.Nowadays the most priority was given to RNA viral genome or otherwise virome.Gene 16srRNA was used to analyse the specific bacteria in patients who are infected with the viral load. SARS-CoV-2 is newly emerging virus which causative agent of Corona virus (COVID-19). A phylogenetic analysis of SARS-CoV-2 is highly sub-clade with SARS-CoV. The immunological symptoms of COVID-19 are dysregulation of cytokine production, improper functioning of various organs and the barrier leakage.

 

Keywords: SARS-CoV-2, COVID-19, RNA viruses, Immune system

References

Yuan L, Hensley CH, Mahsoub M, Ramesh AK,Zhou P. Chapter Two - Microbiota in viral infection and disease in humans and farm animals. Progress in Molecular Biology and Translational Science. 2020;171:15-60

Norman JM, Handley SA, Baldridge MT, et al. Disease specific alterations in the enteric virome in inflammatory bowel disease. Cell 2015;160:447–460.

Virgin HW. The Virome in Mammalian Physiology and Disease. Cell. 2014;157:142-150.

Monaco CL, Gootenberg DB, Zhao G, Siedner MJ, Kwon DS,Virgin HW.Altered Virome and BacterialMicrobiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host & Microbe. 2016;19:311-322.

Scarpellini E, Ianiro G, Attili F, Bassanelli C, De Santis A, Gasbarrini A. The human gut microbiota and virome: Potential therapeutic implications. Digestive and Liver Disease. 2015;47:1007–1012.

Faner R, Sibila O, Agustí A, Bernasconi E,Chalmers JD, Huffnagle GB, Manichanh C,

Molyneaux PL, Paredes R, Brocal VP,Ponomarenko J,Sethi S, Dorca J, Monsó E. The microbiome in respiratory medicine: current challenges and future perspectives. Eur Respir J 2017; 49: 1602086.

Nellore A,Fishman JA. The Microbiome, Systemic Immune Function and allotransplantation. Clinical Microbiology Reviews. 2016;29:191-199.

Fuglsang E, Pizzolla A, Krych L, Nielsen DS, Brooks AG, Frøkiær H et al. Changes in Gut Microbiota Prior to Influenza A Virus Infection Do Not Affect ImmuneResponses in Pups or Juvenile Mice. Front. Cell. Infect. Microbiol. 2018;8:319.

Domínguez-Díaz C, García-Orozco A, Riera-Leal A, Padilla-Arellano JR, Fafutis-Morris M.Microbiota and Its Role on Viral Evasion: Is It with Us or Against Us? Front. Cell. Infect. Microbiol. 2019;9:256.

Li N, Ma W-T, Pang M, Fan Q-L, Hua J-L. The CommensalMicrobiota and Viral Infection: AComprehensive Review.Front. Immunol. 2019;10:1551.

Wilks J, Golovkina T. Influence of Microbiota on ViralInfections. PLoS Pathog. 2012;8(5): e1002681.

Groves HT, Higham SL, Moffatt MF,Cox MJ, Tregoning JS. Respiratory viralinfection alters the gut microbiota by inducinginappetence. mBio 11:e03236-19.

O’Dwyer DN, Dickson RP, Moore BB. The Lung Microbiome, Immunity and the Pathogenesis of Chronic Lung Disease1 J Immunol. 2016; 196(12): 4839–4847.

Morris A, Flores SC. Study of the Lung MicrobiomeHave We Reached the End of the Beginning? American Journal of Respiratory and Critical Care Medicine. 2017; 195:15-16.

Yitbarek A, Taha-Abdelaziz K, Hodgins DC, Read L, Nagy E, Weese JS et al. Gut microbiota-mediatedprotection against influenzavirus subtype H9N2 in chickens isassociated with modulation of theinnate responses. Scientific Reports. 2018;8:13189

Yaron JR, Ambadapadi S, Zhang L, Chavan RN, Tibbetts SA, Keinan S et al., Immune protection is dependenton the gut microbiome in a lethalmouse gammaherpesviralinfection. Scientific Reports. 2020;10:2371.

Trottein, F., Sokol, H., Potential causes and consequences of gastrointestinal disorders during a SARS-CoV-2 infection, Cell Reports (2020), doi: https://doi.org/10.1016/j.celrep.2020.107915.

Dhara D,Mohanty A. Gut microbiota and Covid-19- possible link and implications. Virus Research. 2020;285:198018.

Li Y, Ding J, Xiao Y, Xu B, He W, Yang Y et al., 16S rDNA sequencing analysis of upper respiratory tract flora in patientswith influenza H1N1 virus infection. Frontiers in Lab Medicine. 2017;1:16-26.

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Published

2021-02-07