DEVELOPMENT OF READYMADE SOFRAMYCIN WOUND DRESSING

K Ajaykartik

Abstract


Soframycin sulfate is drug use for treatment of infectious wound due to its antimicrobial activity on causative organism (i.e., gram positive and gram negative). In the present work different waxes combination were used for preparation of eight Soframycin sulfate medicated dressing formulation and evaluated for the utility in the treatment. The cotton pad-I shows maximum amount of water absorption among the studied three different cotton pads available in the local market. Cotton pad-I shows highest amount of water absorption, handling capacity.  Hence cotton pad-I is used throughout the formulation for better absorption of excaudate coming out from wound. The in vitro drug release was carried out in pH 7.5 phosphate buffer.  The formulation SSG8 shows the maximum drug release (89.94%).

In the proposed work the formulation SSG1, SSG2, SSG3 were subjected to primary skin irritation test on experimental animal (Rabbits) and health human volunteers. The results shown that the formulations are devoid of any primary skin irritation or sensation of erythema or edema, even after 72 hours of application of the prepared selected formulation.

Soframycin Sulfate medicated gauge with supportive cotton pad can be prepared for the treatment of wounds. These will have additional advantages of water absorption capacity nonadherant, patient compliances, convenience and comfortness with efficient treatment. The physico chemical characterization revealed that all the formulations were found to have uniform weight and size. The primary skin irritation test reveals that the prepared formulations were devoid of any skin irritation of sensitization or erythema or edema in experimental animals like rabbits. IR spectra analysis showed that there was no drug excipient interaction.


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How to cite this article:

Ajaykartik K, Stallin D, RajkumarBharathi M.Rajkumar B, Purushothamrao K, Dr. Prashant S. Sagare, Development of readymade soframycin wound dressing International Journal of Nursing and Medical Science 2018; 7 (3), 01-12.


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