EVALUATION OF ANTI -ASTHMATIC ACTIVITY OF ETHANOLIC EXTRACT ALPINIA CALCARATA

Authors

  • Ravi Prajapati
  • Dr. Prateek Jain
  • Dr. Harshita Jain
  • Basant Khare
  • Arpit Shrivastav

Abstract

Asthma is a chronic inflammatory lung disease that can cause repeated episodes of cough, wheezing and breathing difficulty. There are number of treatments that can help effectively control or sooth the asthmatic condition Drugs which are indicated for the treatment of asthma includes the classes of beta 2 agonists, corticosteroids, leukotriene inhibitors and xanthenes. however side effects are exhibited by all these drugs. Herbal medicine exhibit fewer side effects and they are very much safe. The plant Alpinia calcarata has been traditionally used for various diseases. In present study rhizomes of the plant Alpinia calcarata have been evaluated for the treatment of asthma. The rizhome of plant was collected and subjected to extraction & phytochemical screening. Further in vitro and in vivo anti asthmatic activity of plant was checked. The results showed that histamine induced bronchospasm the ethanolic extract of the plant Alpinia calcarata rhizomes showed significant activity and increase in dose of extract increase % protection. The maximum % protection shown by the plant extract was 60.79 % observed at 200 mg/kg for broncho relaxant study comparable to that of standard drug chlorpheniramine maleate 78.3 %. It was also observed that the ethanolic extract of Alpinia calcarata rhizomes at doses 100 and 200 mg/kg significantly decreased milk induced eosinophils count. Ethanolic extract of Alpinia calcarata rhizomes inhibits contraction produced by histamine in these tissue preparations. Alpinia calcarata rhizome exhibit significant percentage decreased contraction at concentration 0.8 mg/ml. from these results it can be concluded that the Alpinia calcarata exhibits potent anti -asthmatic activity.

 

Keywords: Asthma, Medicinal plants, Alpinia calcarata Broncho relaxant

References

Abramson MJ, Perret JL, Dharmage SC. Distinguishing adult-onset asthma from COPD: a review and a new approach. International Journal of Chronic Obstructive Pulmonary Disease. 2014; 9(9): 945-962.

Rutkowski K, Sowa P, Rutkowska-Talipska J Allergic diseases: the price of civilisational progress. PostepyDermatolAlergol. 2014; 31(2):77-83.

Cookson WO, Moffatt MF. Genetics of asthma and allergic disease. Hum Mol Genet 2000; 9: 2359–2364.

Barnes KC. Evidence for common genetic elements in allergic disease. J Allergy ClinImmunol 2000; 106: S192–S200.

Dunnill MS. The pathology of asthma, with special reference to the changes in the bronchial mucosa. J ClinPathol 1960; 13: 27–33.

Fahy JV. Reducing IgE levels as a strategy for the treatment of asthma. ClinExp Allergy 2000; 30: Suppl. 1, 16–21.

Barnes PJ. Anti-IgE therapy in asthma: rationale and therapeutic potential. Int Arch Allergy Immunol 2000; 123: 196–204

ThalpathaOsumahhna. Department of Ayurveda, Bandaranaikc Memorial Ayurveda Research Institute. 2002. Vol. I 124-126.

Pushpangadan, P. and Atal, C.K. Ethno-medico-Bolanical investigations in Kerala I, Some primitive tribals of Western Ghats and their herbal medicine. Journal of Ethnopharmacology 1984 11(1): 59-77. 13.

Arambewela, L.S.R., Arawwawala, L.D. and Rathnasooriya, W.D. Antinociceptive activities of aqueous and ethanolic extracts of Alpinia calcarata rhizomes in rats. JournalI of Ethno pharmacology 2004. 95(2-3): 311-316.

YuvrajGulia, ManjushaChoudhary. Antiulcer activity of hydro alcoholic extract of Cassia tora Linn using ethanol induced ulcer. International Journal of Pharmacy and Pharmaceutics Sciences 2010; 4(2); 160-163.

Nikhal S.B., Dambe P.A. Ghongade D.B. And Goupale D.C. Hydro alcoholic extraction of Mangifera indica (leaves) by soxhletion. International Journal of Pharmaceutical Sciences 2010.

Dr.C.K. Kokate, Practical Pharmacognosy, 4th ed. Vallabhprakashan, New Delhi. P. 107-111.

Khandelwal K. R., Practical Pharmacognosy, NiraliPrakashan. P. 149- 154.

A. Elumalai and M. ChinnaEswaraiah . Evaluation of acute oral toxicity and anti-ulcer activity of Yucca gloriosa. L in albino wistar rats. International Journal of Pharmacological Screening methods. Vol2. Issue 1.2012, 12-17.

OECD guidelines for testing of chemicals. OECD/OECD 423

PrachiSaxena, Priyanka Saxena. In-vitro and In-vivo Evaluation of Anti- Asthmatic Activity of Rhizomes Extract of Acorus Calamus (Linn.) in Guinea Pigs 2014; vol 3(5), 1-6.

Khaton M Monira, Shaik M Munan. Review on daturametel: a potential medicinal plant GJRMI, Volume 1, Issue 4, 2012, 123–132.

SurendraAdusumallil, Patan Fayaz1, Nagaraju B1, Puranik DS, PurohitShanthraj Anti-asthmatic activity of aqueous extract ofPistacia integerrimagalls 2013; Vol. 2(3), pp. 026 – 032.

Dhirender Kaushik, Ruby Rani. In vivo and In vitro Anti-asthmatic studies of plant Piper longum Linn. International Journal of Pharmacology 2012, ISSN 1881-7775.

Dnyaneshwar J Taur,Dnyaneshwar J Taur1, Ravindra Y PatilRavindra Y Patil. Effect of Abrus precatorius leaves on milk induced leukocytosis and eosinophilia in the management of asthma. Asian Pacific Journal of Tropical Biomedicine (2012) S40- S42.

A. Pandi Selvi, S. Raj Kumar, G. Sandhya. Anti-asthmatic activity of leaves of Cordia subcordata Lam. (Boraginaceae).sian Journal of Pharmaceutical Science & Technology. 2011 ISSN: 2248 – 9185.

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